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PSMA-PET and micro-ultrasound potential in the diagnostic pathway of prostate cancer.
Lopci, E; Lughezzani, G; Castello, A; Colombo, P; Casale, P; Saita, A; Buffi, N M; Guazzoni, G; Chiti, A; Lazzeri, M.
Afiliação
  • Lopci E; Nuclear-Medicine, Humanitas Clinical and Research Hospital-IRCCS, Rozzano, MI, Italy.
  • Lughezzani G; Department of Urology, Humanitas Clinical and Research Hospital-IRCCS, Via Manzoni 56, 20089, Rozzano, MI, Italy. giovanni.lughezzani@humanitas.it.
  • Castello A; Humanitas University, Pieve Emanuele, MI, Italy. giovanni.lughezzani@humanitas.it.
  • Colombo P; Nuclear-Medicine, Humanitas Clinical and Research Hospital-IRCCS, Rozzano, MI, Italy.
  • Casale P; Pathology, Humanitas Clinical and Research Hospital-IRCCS, Rozzano, MI, Italy.
  • Saita A; Department of Urology, Humanitas Clinical and Research Hospital-IRCCS, Via Manzoni 56, 20089, Rozzano, MI, Italy.
  • Buffi NM; Department of Urology, Humanitas Clinical and Research Hospital-IRCCS, Via Manzoni 56, 20089, Rozzano, MI, Italy.
  • Guazzoni G; Department of Urology, Humanitas Clinical and Research Hospital-IRCCS, Via Manzoni 56, 20089, Rozzano, MI, Italy.
  • Chiti A; Humanitas University, Pieve Emanuele, MI, Italy.
  • Lazzeri M; Department of Urology, Humanitas Clinical and Research Hospital-IRCCS, Via Manzoni 56, 20089, Rozzano, MI, Italy.
Clin Transl Oncol ; 23(1): 172-178, 2021 Jan.
Article em En | MEDLINE | ID: mdl-32447644
PURPOSE: To compare the diagnostic performance of 68Ga-PSMA PET/TC with PRI-MUS (prostate risk identification using micro-ultrasound) in the primary diagnosis of prostate cancer (PCa). METHODS: From September till December 2018, we prospectively enrolled 25 candidates to 68Ga-PSMA PET/TRUS (transrectal ultrasound) fusion biopsy and compared them with PRI-MUS. This included patients with persistently elevated PSA and/or PHI (prostate health index) suspicious for PCa, negative digital rectal examination, with either negative or contraindication to mpMRI, and at least one negative biopsy. The diagnostic performance of the two modalities was calculated based on pathology results. RESULTS: Overall, 20 patients were addressed to 68Ga-PSMA PET/TRUS fusion biopsy. Mean SUVmax and SUVratio for PCa lesions resulted significantly higher than in benign lesions (p = 0.041 and 0.011, respectively). Using optimal cut-off points, 68Ga-PSMA PET/CT demonstrated an overall accuracy of 83% for SUVmax ≥ 5.4 and 94% for SUVratio ≥ 2.2 in the detection of clinically significant PCa (GS ≥ 7). On counterpart, PRI-MUS results were: score 3 in nine patients (45%), score 4 in ten patients (50%), and one patient with score 5. PRI-MUS score 4 and 5 demonstrated an overall accuracy of 61% in detecting clinically significant PCa. CONCLUSION: In this highly-selected patient population, in comparison to PRI-MUS, 68Ga-PSMA PET/CT shows a higher diagnostic performance.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Ultrassonografia / Compostos Radiofarmacêuticos / Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada / Isótopos de Gálio / Radioisótopos de Gálio Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália País de publicação: Itália
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Ultrassonografia / Compostos Radiofarmacêuticos / Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada / Isótopos de Gálio / Radioisótopos de Gálio Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália País de publicação: Itália