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Melatonin treatment reverses cognitive and endocrine deficits evoked by a 24-h light exposure in adult zebrafish.
Giacomini, Ana C V V; Teixeira, Kauane H; Marcon, Leticia; Scolari, Naiara; Bueno, Barbara W; Genario, Rafael; de Abreu, Natascha S; Demin, Konstantin A; Galstyan, David S; Kalueff, Allan V; de Abreu, Murilo S.
Afiliação
  • Giacomini ACVV; Postgraduate Program in Environmental Sciences, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
  • Teixeira KH; Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
  • Marcon L; Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
  • Scolari N; Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
  • Bueno BW; Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
  • Genario R; Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
  • de Abreu NS; Faculty of Engineering and Architecture, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
  • Demin KA; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Institute of Experimental Medicine, Almazov National Medical Research Center, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia.
  • Galstyan DS; Granov Scientific Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia.
  • Kalueff AV; School of Pharmacy, Southwest University, Chongqing, China; Ural Federal University, Ekaterinburg, Russia. Electronic address: avkalueff@gmail.com.
  • de Abreu MS; Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA. Electronic address: abreu_murilo@hotmail.com.
Neurosci Lett ; 733: 135073, 2020 08 10.
Article em En | MEDLINE | ID: mdl-32446774
Melatonin is an important pineal hormone that regulates human and animal circadian rhythms and sleep. Mounting clinical and rodent evidence indicates that melatonin also modulates affective behaviors and cognition. The zebrafish (Danio rerio) is rapidly becoming a powerful novel model organism in translational neuroscience research. Here, we evaluate the effects of a 24-h melatonin treatment on behavior and physiology of adult zebrafish with circadian rhythm disturbed by a 24-h light exposure. While such light exposure evoked overt cognitive and neuroendocrine (cortisol) deficits in zebrafish, these effects were reversed by a 24-h melatonin treatment. Collectively, these findings suggest a positive modulation of affective and cognitive phenotypes in zebrafish by melatonin, and reinforce the growing utility of zebrafish models for studying circadian, cognitive and behavioral processes and their neuroendocrine regulation in vivo.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hidrocortisona / Ritmo Circadiano / Cognição / Melatonina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hidrocortisona / Ritmo Circadiano / Cognição / Melatonina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda