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Exposure to per- and polyfluorinated alkyl substances in pregnant Brazilian women and its association with fetal growth.
Souza, Marilia Cristina Oliveira; Saraiva, Maria Conceição Pereira; Honda, Masato; Barbieri, Marco Antônio; Bettiol, Heloisa; Barbosa, Fernando; Kannan, Kurunthachalam.
Afiliação
  • Souza MCO; Laboratório de Toxicologia Analítica e de Sistemas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, 14040-903, Brazil; Department of Pediatrics and Department of Environmental Medicine, New York University School of Medicine, New York, NY,
  • Saraiva MCP; Departamento de Clinica Infantil, Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, 14040-904, Brazil.
  • Honda M; Institute of Nature and Environmental Technology, Kanazawa University, Kakuma, Kanazawa, Ishikawa Prefecture, 920-119, Japan; Department of Pediatrics and Department of Environmental Medicine, New York University School of Medicine, New York, NY, 10016, USA.
  • Barbieri MA; Departamento de Puericultura e Pediatria da Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brazil.
  • Bettiol H; Departamento de Puericultura e Pediatria da Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brazil.
  • Barbosa F; Laboratório de Toxicologia Analítica e de Sistemas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, 14040-903, Brazil. Electronic address: fbarbosa@fcfrp.usp.br.
  • Kannan K; Department of Pediatrics and Department of Environmental Medicine, New York University School of Medicine, New York, NY, 10016, USA; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: kurunthachalam.kannan@nyulangone.org.
Environ Res ; 187: 109585, 2020 08.
Article em En | MEDLINE | ID: mdl-32442788
Research pertaining to exposure of humans to per- and polyfluorinated alkyl substances (PFASs) has received considerable public and regulatory attention in recent years. Although several studies have reported exposure to PFASs by populations in North America and western Europe, such information is still scarce in Latin America, including Brazil. In this study, concentrations of thirteen PFASs were determined in whole blood collected during the second trimester from 252 pregnant Brazilian women. This is a nested case-control study within the Brazilian Ribeirao Preto and Sao Luiz Birth Cohort Study (BRISA) with selected birth outcomes cases (n = 63) and matched controls (n = 189). PFASs concentrations were associated with conditions including preeclampsia, birth weight (BW), preterm birth, and intrauterine growth restriction (IUGR). Among PFASs measured, perfluorooctane sulfonate (PFOS) was found at the highest concentration (range: 1.06-106 ng mL-1 with a median value of 3.41 ng mL-1) which was followed by perfluorooctanoic acid (PFOA, range: 0.11-2.77 ng mL-1 with a median value of 0.20 ng mL-1). A significant positive association of PFOS and PFOA concentrations with fetal growth restriction (p < 0.05) was found. This is the first study to assess whole blood concentrations of PFASs and their effect on fetal growth in pregnant Brazilian women.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Alcanossulfônicos / Nascimento Prematuro / Poluentes Ambientais / Fluorocarbonos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Newborn / Pregnancy País/Região como assunto: America do norte / America do sul / Brasil / Europa Idioma: En Revista: Environ Res Ano de publicação: 2020 Tipo de documento: Article País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Alcanossulfônicos / Nascimento Prematuro / Poluentes Ambientais / Fluorocarbonos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Newborn / Pregnancy País/Região como assunto: America do norte / America do sul / Brasil / Europa Idioma: En Revista: Environ Res Ano de publicação: 2020 Tipo de documento: Article País de publicação: Holanda