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Trends in cervical cancer and its precursor forms to evaluate screening policies in a mid-sized Northeastern Brazilian city.
Lima, Marcela Sampaio; Brito, Érika de Abreu Costa; Siqueira, Hianga Fayssa Fernandes; Santos, Marceli de Oliveira; da Silva, Angela Maria; Nunes, Marco Antonio Prado; Brito, Hugo Leite de Farias; Lima, Marcia Maria Macedo; Cipolotti, Rosana; Lima, Carlos Anselmo.
Afiliação
  • Lima MS; Graduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil.
  • Brito ÉAC; University Hospital, EBSERH, Federal University of Sergipe, Aracaju, Sergipe, Brazil.
  • Siqueira HFF; Graduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil.
  • Santos MO; University Hospital, EBSERH, Federal University of Sergipe, Aracaju, Sergipe, Brazil.
  • da Silva AM; Graduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil.
  • Nunes MAP; University Hospital, EBSERH, Federal University of Sergipe, Aracaju, Sergipe, Brazil.
  • Brito HLF; CONPREV, Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil.
  • Lima MMM; Graduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil.
  • Cipolotti R; University Hospital, EBSERH, Federal University of Sergipe, Aracaju, Sergipe, Brazil.
  • Lima CA; Graduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil.
PLoS One ; 15(5): e0233354, 2020.
Article em En | MEDLINE | ID: mdl-32428033
Cervical cancer is a health issue that disproportionately affects developing countries, where the Papanicolaou test (Pap smear) remains an important screening tool. Brazilian government recommendations have focused screening on the female population aged from 25 to 64 years old. In this study, we examined the incidence and mortality rates of invasive cervical cancer lesions and the incidence rates of in situ precancerous cervical lesions, aiming to calculate their respective statistics over time in a mid-sized Brazilian city, Aracaju. The 1996-2015 database from the Aracaju Cancer Registry and Mortality Information System was used to calculate age standardized rates for all invasive cervical tumors (International code of diseases, ICD-10: C53) and preinvasive cervical lesions (ICD-10: D06) in the following patient age ranges; ≤ 24, 25-34, 35-44, 45-54, 55-64 and ≥ 65 years old. We identified 1,030 cancer cases, 1,871 in situ lesions and 334 deaths. Using the Joinpoint Regression Program, we calculated the annual percentage incidence changes and our analyses show that cervical cancer incidence decreased up to 2008, increased up to 2012 and decreased again thereafter, a significant trend in all age groups from 25 years. The incidence of precursor lesions increased from 1996 to 2005 and has since decreased, a result significant in all age groups until 64 years. Cervical cancer mortality has decreased by 3.8% annually and trend analysis indicates that Pap smears have been effective in decreasing cancer incidence and mortality. However, recent trends shown here show a decreasing incidence of in situ lesions and may indicate either a real decrease or incomplete catchment. Thus, we suggest health policies should be re-considered and include sufficient screening and HPV vaccination strategies to avoid cervical cancer resurgence in the population.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo do Útero / Detecção Precoce de Câncer Limite: Adult / Female / Humans / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo do Útero / Detecção Precoce de Câncer Limite: Adult / Female / Humans / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos