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Hydroethanolic Extract of Solanum paniculatum L. Fruits Modulates ROS and Cytokine in Human Cell Lines.
Ferraz, Ana Paula C R; Sussulini, Alessandra; Garcia, Jéssica L; Costa, Mariane R; Francisqueti-Ferron, Fabiane V; Ferron, Artur J T; Silva, Carol Cristina V de A; Corrente, José Eduardo; Manfio, Vanessa M; Namba, Vickeline; Lima, Giuseppina P P; Pereira, Bismarque S; Fecchio, Denise; Minatel, Igor O; Dos Santos, Klinsmann C; Corrêa, Camila R.
Afiliação
  • Ferraz APCR; São Paulo State University (UNESP), Medical School, Botucatu 18618-687, Brazil.
  • Sussulini A; University of Campinas (UNICAMP), Institute of Chemistry, Campinas 6154, Brazil.
  • Garcia JL; São Paulo State University (UNESP), Medical School, Botucatu 18618-687, Brazil.
  • Costa MR; São Paulo State University (UNESP), Medical School, Botucatu 18618-687, Brazil.
  • Francisqueti-Ferron FV; São Paulo State University (UNESP), Medical School, Botucatu 18618-687, Brazil.
  • Ferron AJT; São Paulo State University (UNESP), Medical School, Botucatu 18618-687, Brazil.
  • Silva CCVA; São Paulo State University (UNESP), Medical School, Botucatu 18618-687, Brazil.
  • Corrente JE; São Paulo State University (UNESP), Medical School, Botucatu 18618-687, Brazil.
  • Manfio VM; São Paulo State University (UNESP), Medical School, Botucatu 18618-687, Brazil.
  • Namba V; São Paulo State University (UNESP), Medical School, Botucatu 18618-687, Brazil.
  • Lima GPP; São Paulo State University (UNESP), Institute of Biosciences, Botucatu, 18618-689 São Paulo, Brazil.
  • Pereira BS; São Paulo State University (UNESP), Medical School, Botucatu 18618-687, Brazil.
  • Fecchio D; São Paulo State University (UNESP), Medical School, Botucatu 18618-687, Brazil.
  • Minatel IO; São Paulo State University (UNESP), Institute of Biosciences, Botucatu, 18618-689 São Paulo, Brazil.
  • Dos Santos KC; São Paulo State University (UNESP), Medical School, Botucatu 18618-687, Brazil.
  • Corrêa CR; São Paulo State University (UNESP), Medical School, Botucatu 18618-687, Brazil.
Oxid Med Cell Longev ; 2020: 7240216, 2020.
Article em En | MEDLINE | ID: mdl-32411334
Solanum paniculatum L. or popularly known as "jurubeba" is an herbal medicinal plant. A few studies have investigated its biological effects; however, research aimed at elucidating the redox balance effects from its fruits has not been reported so far. ROS interplays in various fields of medicine such as chemotherapy. Here, we evaluated antioxidant and inflammatory activities of the hydroethanolic extract of Solanum Paniculatum L. (HESPL) fruits in breast cancer cells, as well as its phytochemical profile. The antioxidant profile (carotenoids and phenolic compounds) was obtained by HPLC-DAD-UV and HPLC-APCI-MS. Cancer cell lines and human vein endothelial cells (HUVECs) were cultivated and treated with 1.87-30 µg/mL of HESPL for 24 hrs. Cytotoxicity, oxidative, and inflammation biomarkers were evaluated. The dose of 30 µg/mL of the HESPL extract presented cytotoxicity in the MCF-7 cell line. However, for MDA-MB-231, the cytotoxicity was observed in the dose of 1.87 g/mL. The 1.87 µg/mL and 3.75 µg/mL doses decreased the concentration of IL-6 in MCF-7 cells. In the MDA-MB-231 cells, the HESPL did not decrease the IL-6 concentration; however, in the doses of 15 and 30 µg/mL, an increase in this parameter was observed. The HESPL increased IL-1ß concentration in HUVECs. The ROS level in MCF-7 was elevated only at the 30 µg/ml dose. Regarding MDA-MB-231, HESPL promoted increased ROS levels at all doses tested. HUVEC showed no increase in ROS under any dose. HESPL treatment may modulate cytotoxicity, ROS, and cytokine levels due to its phytochemical profile, and it has shown an antioxidant or anti-inflammatory effect.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Água / Extratos Vegetais / Citocinas / Espécies Reativas de Oxigênio / Solanum / Etanol / Frutas Limite: Humans Idioma: En Revista: Oxid Med Cell Longev Assunto da revista: METABOLISMO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Água / Extratos Vegetais / Citocinas / Espécies Reativas de Oxigênio / Solanum / Etanol / Frutas Limite: Humans Idioma: En Revista: Oxid Med Cell Longev Assunto da revista: METABOLISMO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos