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Onychomycosis in Psoriatic Patients with Nail Disorders: Aetiological Agents and Immunosuppressive Therapy.
Alves, Núbia Carvalho Pena de Oliveira Praeiro; Moreira, Tomaz de Aquino; Malvino, Lucivânia Duarte Silva; Rodrigues, José Joaquim; Ranza, Roberto; de Araújo, Lúcio Borges; Pedroso, Reginaldo Dos Santos.
Afiliação
  • Alves NCPOP; Postgraduate Program in Health Sciences, School of Medicine, Federal University of Uberlândia, Pará Av. 1720, Umuarama, Uberlândia, Minas Gerais, Brazil.
  • Moreira TA; Rheumatology Service of the Clinical Hospital of Uberlândia, Federal University of Uberlândia, Pará Av. 1720, Umuarama, Uberlândia, Minas Gerais, Brazil.
  • Malvino LDS; Clinical Analysis Laboratory of the Clinical Hospital of Uberlândia, Federal University of Uberlândia, Pará Av. 1720, Umuarama, Uberlândia, Minas Gerais, Brazil.
  • Rodrigues JJ; Clinical Analysis Laboratory of the Clinical Hospital of Uberlândia, Federal University of Uberlândia, Pará Av. 1720, Umuarama, Uberlândia, Minas Gerais, Brazil.
  • Ranza R; Rheumatology Service of the Clinical Hospital of Uberlândia, Federal University of Uberlândia, Pará Av. 1720, Umuarama, Uberlândia, Minas Gerais, Brazil.
  • de Araújo LB; Rheumatology Service of the Clinical Hospital of Uberlândia, Federal University of Uberlândia, Pará Av. 1720, Umuarama, Uberlândia, Minas Gerais, Brazil.
  • Pedroso RDS; Federal University of Uberlândia, João Naves de Ávila Av. 120, 1F Block, Santa Monica, Uberlândia, Minas Gerais, Brazil.
Dermatol Res Pract ; 2020: 7209518, 2020.
Article em En | MEDLINE | ID: mdl-32411192
Psoriasis and psoriatic arthritis are chronic, relapsing, immune-based diseases. Psoriatic patients may have nail involvement in 50 to 80% of cases, and this may reach 85% in patients with joint disease, in spite of the fact that the relationship between psoriasis and onychomycosis is not well established. The aim of this study was to investigate the occurrence of onychomycosis in patients with nail disorders and diagnosis of psoriasis and psoriatic arthritis. This was a cross-sectional study in which 38 patients diagnosed with psoriasis and/or psoriatic arthritis were interviewed and had altered nail samples analysed by mycological and histopathological exams. Twenty-two (57.89%) patients had a confirmed diagnosis for onychomycosis. Seventeen (44.8%) had a positive direct mycological examination, 16 (42.1%) had positive cultures, and 12 (31.6%) were positive for fungi by histopathological examination. Dermatophytes were identified in nine (56.3%) cultures, and of these, eight were Trichophyton rubrum and one T. tonsurans. Yeasts were isolated in seven patients (43.75%), which included four Candida parapsilosis and three C. albicans. Six patients (15.78%) were not using immunosuppressive therapy, and the others were using methotrexate, etanercept, adalimumab, infliximab, secukinumab, or golimumab, in monotherapy or in combination with other drugs. The confirmed onychomycosis rate in patients using methotrexate alone was 92.8% (n = 13). We concluded that it is possible that there is a positive relationship between psoriatic disease and onychomycosis. And we highlight that it is also worth investigating in the future the possible role of immunosuppressive therapy (mainly methotrexate) as a predisposing factor for the development of fungal infections in psoriatic patients.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Dermatol Res Pract Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Egito

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Dermatol Res Pract Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Egito