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Bioactive Compounds from the Aerial Parts of Evolvulus linarioides.
Pereira, Laiane C O; Abreu, Lucas S; Silva, Joanda P R E; Machado, Francisca S V L; Queiroga, Cinthia S; do Espi Rito-Santo, Renan F; Agnelo-Silva, Diego F de; Villarreal, Cristiane F; Agra, Maria de F; Scotti, Marcus T; Costa, Vicente C de O; Tavares, Josean F; Silva, Marcelo S da.
Afiliação
  • Pereira LCO; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, Brazil.
  • Abreu LS; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, Brazil.
  • Silva JPRE; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, Brazil.
  • Machado FSVL; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, Brazil.
  • Queiroga CS; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, Brazil.
  • do Espi Rito-Santo RF; Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Brazil.
  • Agnelo-Silva DF; School of Pharmacy, Federal University of Bahia, Salvador, Brazil.
  • Villarreal CF; School of Pharmacy, Federal University of Bahia, Salvador, Brazil.
  • Agra MF; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, Brazil.
  • Scotti MT; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, Brazil.
  • Costa VCO; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, Brazil.
  • Tavares JF; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, Brazil.
  • Silva MSD; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, Brazil.
J Nat Prod ; 83(5): 1515-1523, 2020 05 22.
Article em En | MEDLINE | ID: mdl-32364737
Three new caryophyllane-type sesquiterpenoids, linariophyllenes A-C (1-3), two new hamamelitol derivatives, linaritols A (4) and B (5), two new chromones, linariosides A (6) and B (7), and three known chromones, cnidimol C (8), monnieriside A (9), and undulatoside A (10), were identified from the aerial parts of Evolvulus linarioides. The structures of these compounds were elucidated by NMR, MS, and IR data. The absolute configurations of compounds 1-5 and 7 were established via electronic circular dichroism data. The anti-inflammatory potential of compounds 1-5 and 7-10 was evaluated by determining their ability to inhibit the production of nitric oxide (NO) and proinflammatory cytokine IL-1ß by stimulated J774 macrophages. Compounds tested at noncytotoxic concentrations inhibited NO production by macrophages, exhibiting IC50 values between 17.8 and 66.2 µM, and inhibited IL-1ß production by stimulated macrophages by 72.7-96.2%.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Convolvulaceae / Componentes Aéreos da Planta Limite: Animals Idioma: En Revista: J Nat Prod Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Convolvulaceae / Componentes Aéreos da Planta Limite: Animals Idioma: En Revista: J Nat Prod Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos