Your browser doesn't support javascript.
loading
Drug polarity effect over the controlled release in casein and chondroitin sulfate-based hydrogels.
Simão, Andressa Renatta; Fragal, Vanessa H; Pellá, Michelly Cristina Galdioli; Garcia, Francielle P; Nakamura, Celso V; Silva, Rafael; Tambourgi, Elias B; Rubira, Adley F.
Afiliação
  • Simão AR; Chemistry Department, State University of Maringa, Colombo Av. 5790, 87020-900 Maringa, Parana, Brazil.
  • Fragal VH; Chemistry Department, State University of Maringa, Colombo Av. 5790, 87020-900 Maringa, Parana, Brazil; University of Campinas, Faculty of Chemical Engineering, Cidade Universitária Zeferino Vaz, Campinas, SP, Brazil. Electronic address: vhfragal2@uem.br.
  • Pellá MCG; Chemistry Department, State University of Maringa, Colombo Av. 5790, 87020-900 Maringa, Parana, Brazil.
  • Garcia FP; Department of Basic Sciences of Health, State University of Maringa, Colombo, Av. 5790, ZIP code: 87020-900. Maringa, Parana, Brazil.
  • Nakamura CV; Department of Basic Sciences of Health, State University of Maringa, Colombo, Av. 5790, ZIP code: 87020-900. Maringa, Parana, Brazil; Graduate Program in Pharmaceutical Sciences, Department of Basic Science of Health, State University of Maringa, Av. Colombo, 5790, 87020-900 Maringá, Paraná, Brazil.
  • Silva R; Chemistry Department, State University of Maringa, Colombo Av. 5790, 87020-900 Maringa, Parana, Brazil.
  • Tambourgi EB; University of Campinas, Faculty of Chemical Engineering, Cidade Universitária Zeferino Vaz, Campinas, SP, Brazil.
  • Rubira AF; Chemistry Department, State University of Maringa, Colombo Av. 5790, 87020-900 Maringa, Parana, Brazil. Electronic address: afrubira@uem.br.
Int J Biol Macromol ; 2020 Apr 25.
Article em En | MEDLINE | ID: mdl-32344082
This study compared the controlled release of two drugs: vitamin-B12, and l-dopa from hydrogels based on 50% of casein (CAS, a protein), 50% of chondroitin sulfate (CS, a polysaccharide) and different amounts of SiO2. The results indicated that the incorporation of 5% of SiO2 to the materials, allowed the best organization, distribution, and diameter of the pores, which are responsible for ensuring a more controlled release. Also, the matrices were not efficient in releasing vitamin-B12, but it successfully released l-dopa. It happened because vitamin-B12 is highly hydrophilic, interacting more with the medium than with the CAS/CS matrix, while l-dopa is less polar than vitamin-B12, interacting more with the CAS/CS matrix. It is worth mentioning that all synthesized hydrogels were non-toxic to the cells as showed by the in vitro assay. This work also demonstrated the importance of evaluating drug delivery devices using drugs of different polarities before stating if they are efficient or not.
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda