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Genetic variations associated with pharmacoresistant epilepsy (Review).
Cárdenas-Rodríguez, Noemí; Carmona-Aparicio, Liliana; Pérez-Lozano, Diana L; Ortega-Cuellar, Daniel; Gómez-Manzo, Saúl; Ignacio-Mejía, Iván.
Afiliação
  • Cárdenas-Rodríguez N; Laboratory of Neuroscience, National Institute of Pediatrics, Ministry of Health, Coyoacán, Mexico City 04530, Mexico.
  • Carmona-Aparicio L; Laboratory of Neuroscience, National Institute of Pediatrics, Ministry of Health, Coyoacán, Mexico City 04530, Mexico.
  • Pérez-Lozano DL; Laboratory of Neuroscience, National Institute of Pediatrics, Ministry of Health, Coyoacán, Mexico City 04530, Mexico.
  • Ortega-Cuellar D; Laboratory of Experimental Nutrition, National Institute of Pediatrics, Ministry of Health, Coyoacán, Mexico City 04530, Mexico.
  • Gómez-Manzo S; Laboratory of Genetic Biochemistry, National Institute of Pediatrics, Ministry of Health, Coyoacán, Mexico City 04530, Mexico.
  • Ignacio-Mejía I; Laboratory of Translational Medicine, Military School of Health Graduates, Lomas de Sotelo, Militar, Mexico City 11200, Mexico.
Mol Med Rep ; 21(4): 1685-1701, 2020 04.
Article em En | MEDLINE | ID: mdl-32319641
Epilepsy is a common, serious neurological disorder worldwide. Although this disease can be successfully treated in most cases, not all patients respond favorably to medical treatments, which can lead to pharmacoresistant epilepsy. Drug­resistant epilepsy can be caused by a number of mechanisms that may involve environmental and genetic factors, as well as disease­ and drug­related factors. In recent years, numerous studies have demonstrated that genetic variation is involved in the drug resistance of epilepsy, especially genetic variations found in drug resistance­related genes, including the voltage­dependent sodium and potassium channels genes, and the metabolizer of endogenous and xenobiotic substances genes. The present review aimed to highlight the genetic variants that are involved in the regulation of drug resistance in epilepsy; a comprehensive understanding of the role of genetic variation in drug resistance will help us develop improved strategies to regulate drug resistance efficiently and determine the pathophysiological processes that underlie this common human neurological disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Resistência a Medicamentos / Epilepsia Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Mol Med Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: México País de publicação: Grécia
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Resistência a Medicamentos / Epilepsia Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Mol Med Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: México País de publicação: Grécia