Your browser doesn't support javascript.
loading
Immunostaining study of cytokeratins in human hair follicle development.
Silva, Laura Maria Andrade; Hsieh, Ricardo; Lourenço, Silvia Vanessa; Valente, Neusa Yuriko Sakai; Paiva, Geise Rezende; Fernandes, Juliana Dumet.
Afiliação
  • Silva LMA; Graduate Program in Medicine and Health, Faculty of Medicine of Bahia, Universidade Federal da Bahia, Salvador, BA, Brazil; Service of Dermatology, Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, Brazil; Service of Dermatology, Hospital Santa Izabel, Salvador, BA, Brazil; Department of Der
  • Hsieh R; Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, SP, Brazil; Department of Pathology, Universidade Federal de Alfenas, Alfenas, MG, Brazil.
  • Lourenço SV; Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, SP, Brazil; Faculdade de Odontologia, Universidade de São Paulo, São Paulo, SP, Brazil.
  • Valente NYS; Department of Dermatology, Faculdade de Medicina, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP, Brazil.
  • Paiva GR; Sector of Pathology, Hospital Santa Izabel, Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, Brazil.
  • Fernandes JD; Graduate Program in Medicine and Health, Faculty of Medicine of Bahia, Universidade Federal da Bahia, Salvador, BA, Brazil; Department of Dermatology, Faculdade de Medicina, Universidade Federal da Bahia, Salvador, BA, Brazil.
An Bras Dermatol ; 95(3): 278-282, 2020.
Article em En | MEDLINE | ID: mdl-32299738
BACKGROUND: The hair follicle is a unique structure, one of the most dynamic structures in mammalians, which can reproduce in every new cycle all the mechanism involved in its fetal development. Although a lot of research has been made about the human hair follicle much less has been discovered about the importance of the cytokeratins (CKs) in its development. OBJECTIVE: Study the immunohistochemical pattern of epithelial CKs during human hair follicle development. METHODS: We performed an immunohistochemical study using fresh post-mortem skin biopsies of human fetuses between 4 and 25 weeks of gestational age to study the expression of cytokeratins (CKs): CK1, CK10, CK13, CK14, CK16 and CK20 during human hair follicle fetal development. STUDY LIMITATIONS: Restrospective study with a good number of makers but with a small population. RESULTS/CONCLUSION: We found that, the CKs were expressed in an intermediate time during follicular development. The epithelial CKs (CK1, CK14, CK10, CK13) and the epithelial CKs with a proliferative character such as CK16 were expressed first, as markers of cellular maturation and follicular keratinization. At a later phase, CK20 was expressed in more developed primitive hair follicles as previously discussed in literature.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Folículo Piloso / Queratinas Específicas do Cabelo Tipo de estudo: Observational_studies Limite: Humans Idioma: En Revista: An Bras Dermatol Ano de publicação: 2020 Tipo de documento: Article País de publicação: Espanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Folículo Piloso / Queratinas Específicas do Cabelo Tipo de estudo: Observational_studies Limite: Humans Idioma: En Revista: An Bras Dermatol Ano de publicação: 2020 Tipo de documento: Article País de publicação: Espanha