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Cytotoxicity and antibacterial activity of scutellarein and carajurone-enriched fraction obtained from the hydroethanolic extract of the leaves of Fridericia chica (Bonpl.) L.G. Lohmann.
Violante, Ivana M P; Carollo, Carlos A; Silva, Larissa I; Oliveira, Adna Q C; Pardinho, Flavia C; Garcez, Walmir Silva; Garcez, Fernanda R; Oliveira, Ruberlei Godinho de; Arunachalam, Karuppusamy; de Oliveira Martins, Domingos Tabajara.
Afiliação
  • Violante IMP; Area of Pharmacology, Department of Basic Sciences in Health, Faculty of Medicine, Federal University of Mato Grosso (UFMT), Cuiabá, Mato Grosso, Brazil.
  • Carollo CA; Pharmacognosy Laboratory, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
  • Silva LI; Area of Pharmacology, Department of Basic Sciences in Health, Faculty of Medicine, Federal University of Mato Grosso (UFMT), Cuiabá, Mato Grosso, Brazil.
  • Oliveira AQC; Area of Pharmacology, Department of Basic Sciences in Health, Faculty of Medicine, Federal University of Mato Grosso (UFMT), Cuiabá, Mato Grosso, Brazil.
  • Pardinho FC; Area of Pharmacology, Department of Basic Sciences in Health, Faculty of Medicine, Federal University of Mato Grosso (UFMT), Cuiabá, Mato Grosso, Brazil.
  • Garcez WS; Center of Exact Sciences and Technology, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
  • Garcez FR; Center of Exact Sciences and Technology, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
  • Oliveira RG; Area of Pharmacology, Department of Basic Sciences in Health, Faculty of Medicine, Federal University of Mato Grosso (UFMT), Cuiabá, Mato Grosso, Brazil.
  • Arunachalam K; Area of Pharmacology, Department of Basic Sciences in Health, Faculty of Medicine, Federal University of Mato Grosso (UFMT), Cuiabá, Mato Grosso, Brazil.
  • de Oliveira Martins DT; Area of Pharmacology, Department of Basic Sciences in Health, Faculty of Medicine, Federal University of Mato Grosso (UFMT), Cuiabá, Mato Grosso, Brazil.
Nat Prod Res ; 35(23): 5287-5293, 2021 Dec.
Article em En | MEDLINE | ID: mdl-32290696
The hydroethanolic extract obtained from the dry leaves of Fridericia chica (HEFc) underwent several fractionations by different chromatographic techniques. The ethyl acetate and dichloromethane fraction were subjected to phytochemical analysis, resulting in the identification and isolation of scutellarein (1) and in a fraction rich in carajurone (2). They were tested for cytotoxicity in CHO-K1 and the antibacterial activity and mode of action by in vitro assays. The HEFc and scutellarein (1) presented no cytotoxicity. The results showed good antibacterial effect of HEFc against Streptococcus pyogenes and Staphylococcus aureus and moderate activity for Staphylococcus epidermidis, Pseudomonas aeruginosa and Salmonella typhimurium. The fraction containing the compound carajurone (2) showed good activity against Staphylococcus aureus and Staphylococcus epidermidis and moderate activity against Streptococcus pyogenes. Scutellarein (1) showed no activity against the bacteria tested. HEFc antibacterial mode of action appeared to be associated with changes in the permeability of bacterial membranes and nucleotide leakage.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Folhas de Planta Idioma: En Revista: Nat Prod Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Folhas de Planta Idioma: En Revista: Nat Prod Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido