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Campomanesia sp. flour attenuates non-alcoholic fatty liver disease on rats fed with a hypercaloric diet.
Loubet Filho, Paulo Sérgio; Santos, Thayná Gil; Reis, Vitória Helena de Oliveira Teixeira; Santee, Cynthia Monteiro; da Costa, Matheus Pereira; Cândido, Camila Jordão; Filiú, Wander Fernando de Oliveira; Portugal, Luciane Candeloro; Dos Santos, Elisvânia Freitas.
Afiliação
  • Loubet Filho PS; College of Pharmacy, Food and Nutrition, Nutrition Course, Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
  • Santos TG; College of Pharmacy, Food and Nutrition, Nutrition Course, Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
  • Reis VHOT; College of Pharmacy, Food and Nutrition, Nutrition Course, Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
  • Santee CM; College of Pharmacy, Food and Nutrition, Nutrition Course, Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
  • da Costa MP; College of Pharmacy, Food and Nutrition, Pharmacy Course, Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
  • Cândido CJ; College of Pharmacy, Food and Nutrition, Pharmacy Course, Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
  • Filiú WFO; College of Pharmacy, Food and Nutrition, Pharmacy Course, Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
  • Portugal LC; Histology Laboratory, College of Bioscience, Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
  • Dos Santos EF; College of Pharmacy, Food and Nutrition, Nutrition Course, Postgraduate Program on Health and Development of Middle-West, Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
J Anim Physiol Anim Nutr (Berl) ; 104(5): 1575-1582, 2020 Sep.
Article em En | MEDLINE | ID: mdl-32279410
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder caused by excess consumption of hypercaloric foods. Guavira (Campomanesia sp.) pulp has broad technological applicability, yet the peel and seeds are considered industrial residue. The objective of this unprecedented study was to evaluate the effects of the flour from guavira's industrial residue (GF) consumption in rats fed with hypercaloric diet (HD). During 65 days, 50 rats were separated into a control group: 1%, 2%, 4% and 8% HD with GF complementation in the diet. The GF chemical composition, phenolic compounds, antioxidant capacity, serum biochemical parameters (glucose, cholesterol, HDL, non-HDL, triglycerides, AST, ALT, and oral glucose tolerance test), fat liver content, and hepatic histomorphology had been characterized. GF is mainly composed of fibres, with phenolic content of 7,391.09 mg AGE/100 g GF and relevant antioxidant capacity (IC50 2.22 and ORAC 155.68 µmol/TE g-1 ). Serum biochemical analysis did not differ statistically (except ALT reduction, p < .05). Fat liver content was smaller on HD2%GF (p < .0001). The control group and 1% GF showed greater diffuse microvesicular steatosis compared to the other groups when using hepatic morphological analysis (p < .05). GF consumption attenuated NAFLD caused by a hypercaloric diet, and this effect may be related to the fibre content and bioactive compounds in GF.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ingestão de Energia / Myrtaceae / Hepatopatia Gordurosa não Alcoólica / Ração Animal Limite: Animals Idioma: En Revista: J Anim Physiol Anim Nutr (Berl) Assunto da revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / MEDICINA VETERINARIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ingestão de Energia / Myrtaceae / Hepatopatia Gordurosa não Alcoólica / Ração Animal Limite: Animals Idioma: En Revista: J Anim Physiol Anim Nutr (Berl) Assunto da revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / MEDICINA VETERINARIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha