Your browser doesn't support javascript.
loading
Resistance training decreases matrix metalloproteinase-2 activity in quadriceps tendon in a rat model of osteoarthritis.
Vasilceac, Fernando Augusto; Marqueti, Rita de Cássia; Neto, Ivo Vieira de Sousa; Nascimento, Dahan da Cunha; Souza, Mariana Carvalho de; Durigan, João Luiz Quaglioti; Mattiello, Stela Márcia.
Afiliação
  • Vasilceac FA; Graduate Program of Physical Therapy, Universidade Federal de São Carlos (UFSCar), São Carlos, São Paulo, Brazil.
  • Marqueti RC; Graduate Program of Sciences and Technology of Health, Universidade de Brasília (UnB), Brasília, Distrito Federal, Brazil; Graduate Program in Rehabilitation Sciences, Universidade de Brasília (UnB), Brasília, Distrito Federal, Brazil. Electronic address: marqueti@gmail.com.
  • Neto IVS; Graduate Program of Sciences and Technology of Health, Universidade de Brasília (UnB), Brasília, Distrito Federal, Brazil.
  • Nascimento DDC; Graduate Program of Physical Education, Universidade Católica de Brasília (UCB), Brasília, Distrito Federal, Brazil; Department of Physical Education, Centro Universitário do Distrito Federal, Brasília, Distrito Federal, Brazil.
  • Souza MC; Graduate Program of Physical Therapy, Universidade Federal de São Carlos (UFSCar), São Carlos, São Paulo, Brazil.
  • Durigan JLQ; Graduate Program of Sciences and Technology of Health, Universidade de Brasília (UnB), Brasília, Distrito Federal, Brazil; Graduate Program in Rehabilitation Sciences, Universidade de Brasília (UnB), Brasília, Distrito Federal, Brazil.
  • Mattiello SM; Graduate Program of Physical Therapy, Universidade Federal de São Carlos (UFSCar), São Carlos, São Paulo, Brazil.
Braz J Phys Ther ; 25(2): 147-155, 2021.
Article em En | MEDLINE | ID: mdl-32276877
BACKGROUND: Osteoarthritis (OA) is a degenerative disease that induces peri-articular tissue degradation. OA induces an imbalance between synthesis and degradation of the extracellular matrix components in favor of catabolic events, promoting pathological remodeling and involving degradative enzymes, such as matrix metalloproteinases (MMPs). OBJECTIVE: This study aimed to investigate the effects of 8-weeks resistance training (RT) on MMP-2 activity in the quadriceps tendon and patellar tendon in an OA model. METHODS: Twenty-four Wistar rats were randomly divided into six groups: Control, Exercise, Sham, Sham with Exercise, OA, and OA with Exercise (OAE). The OA model was performed by anterior cruciate ligament transection surgery on the left knee. The 8-week RT consisted of climbing a 1.1-m vertical ladder three times per week with progressive weights secured to the animals' tails. MMP-2 activity was analyzed by zymography. RESULTS: The OAE group displayed lower pro, intermediate, and active MMP-2 activity in the quadriceps tendon compared with the OA group (p<0.05). For the patellar tendon, there was no significant difference between the OAE group compared with the other groups (p>0.05) for pro, intermediate, and active MMP-2 activity. Moreover, MMP-2 activity differed between tissues, the OA and OAE groups presented lower pro, intermediate, and active MMP-2 activity in the quadriceps tendon compared to the patellar tendon. CONCLUSION: RT induced down-regulated MMP-2 activity in the quadriceps tendon. RT is a potential therapeutic approach to minimize the deleterious effects of extracellular matrix degeneration.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite / Metaloproteinase 2 da Matriz / Músculo Quadríceps / Treinamento Resistido Limite: Animals Idioma: En Revista: Braz J Phys Ther Assunto da revista: MEDICINA FISICA / REABILITACAO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite / Metaloproteinase 2 da Matriz / Músculo Quadríceps / Treinamento Resistido Limite: Animals Idioma: En Revista: Braz J Phys Ther Assunto da revista: MEDICINA FISICA / REABILITACAO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil