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Evaluation of the effectiveness of high-risk human papilloma self-sampling test for cervical cancer screening in Bolivia.
Allende, Gustavo; Surriabre, Pedro; Ovando, Neli; Calle, Pamela; Torrico, Andrea; Villarroel, Jaime; Bossens, Michel; Fontaine, Véronique; Rodriguez, Patricia.
Afiliação
  • Allende G; Laboratory of Virology, Faculty of Medicine, Universidad Mayor de San Simón, Cochabamba, Bolivia.
  • Surriabre P; Unité de Microbiologie Pharmaceutique et Hygiène, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), CP205/2, Campus Plaine, Boulevard du Triomphe, 1050, Brussels, Belgium.
  • Ovando N; Laboratory of Virology, Faculty of Medicine, Universidad Mayor de San Simón, Cochabamba, Bolivia.
  • Calle P; Unité de Microbiologie Pharmaceutique et Hygiène, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), CP205/2, Campus Plaine, Boulevard du Triomphe, 1050, Brussels, Belgium.
  • Torrico A; Laboratory of Virology, Faculty of Medicine, Universidad Mayor de San Simón, Cochabamba, Bolivia.
  • Villarroel J; Laboratory of Virology, Faculty of Medicine, Universidad Mayor de San Simón, Cochabamba, Bolivia.
  • Bossens M; Laboratory of Virology, Faculty of Medicine, Universidad Mayor de San Simón, Cochabamba, Bolivia.
  • Fontaine V; Anatomopathology Laboratory of the Bolivian-Japanese hospital, Cochabamba, Bolivia.
  • Rodriguez P; Research Laboratory in Human Reproduction, Campus Erasme, Faculty of Medicine, Universite libre de Bruxelles, Brussels, ULB, Belgium.
BMC Infect Dis ; 20(1): 259, 2020 Apr 03.
Article em En | MEDLINE | ID: mdl-32245369
BACKGROUND: In Bolivia the incidence and mortality rates of uterine cervix cancer are the highest in America. The main factor contributing to this situation is the difficulty of establishing and maintaining quality prevention programs based on cytology. We aimed to evaluate the effectiveness of HR-HPV testing on self-collected samples to detect cervical intra-epithelial neoplasia and identify the best combination of screening tests. METHODS: A total of 469 women, divided in two groups, were included in this study. The first group included 362 women that underwent three consecutively primary screening tests: self-collected sampling for HR-HPV detection, conventional cervical cytology and visual inspection under acetic acid (VIA). The second group included 107 women referred with a positive HR-HPV test that underwent conventional cervical cytology and VIA. The presence of high grade intraepithelial lesion (CIN 2+) or invasive cancer was verified by colposcopy and biopsy. RESULT: In the screening group the sensitivity to detect high grade intraepithelial lesion (CIN 2+) or invasive cancer were 100, 76, 44% for the VIA, HR-HPV test and cytology, respectively. In the referred group, the sensitivity to detect high grade intraepithelial lesion (CIN 2+) or invasive cancer by VIA and cytology were 100 and 81%, respectively. CONCLUSIONS: VIA and HR-HPV self-sampling were the best combination to detect CIN2+ lesions. Cytology analysis gave the poorest performance.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Papillomaviridae / Neoplasias do Colo do Útero / Programas de Rastreamento / Infecções por Papillomavirus Tipo de estudo: Diagnostic_studies / Etiology_studies / Evaluation_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Adult / Female / Humans / Middle aged País/Região como assunto: America do sul / Bolivia Idioma: En Revista: BMC Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Bolívia País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Papillomaviridae / Neoplasias do Colo do Útero / Programas de Rastreamento / Infecções por Papillomavirus Tipo de estudo: Diagnostic_studies / Etiology_studies / Evaluation_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Adult / Female / Humans / Middle aged País/Região como assunto: America do sul / Bolivia Idioma: En Revista: BMC Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Bolívia País de publicação: Reino Unido