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Serum levels of matrix metalloproteinase-2, -9, and vitamin D in patients with multiple sclerosis with or without herpesvirus-6 seropositivity.
Amini, Razieh; Karampoor, Sajad; Zahednasab, Hamid; Keyvani, Hossein; Gheiasian, Masoud; Jalilian, Farid Azizi.
Afiliação
  • Amini R; Hamadan University of Medical Sciences, Faculty of Medicine, Department of Molecular Medicine and Genetics, Hamadan, Iran.
  • Karampoor S; Iran University of Medical Sciences, School of Medicine, Department of Virology, Tehran, Iran. Electronic address: Sajadkarampour1987@gmail.com.
  • Zahednasab H; University of Tehran, Institute of Biochemistry and Biophysics, Tehran, Iran.
  • Keyvani H; Iran University of Medical Sciences, School of Medicine, Department of Virology, Tehran, Iran.
  • Gheiasian M; Hamadan University of Medical Sciences, Faculty of Medicine, Department of Neurology, Hamadan, Iran.
  • Jalilian FA; Hamadan University of Medical Sciences, Faculty of Medicine Hamadan, Department of Medical Virology, Hamadan, Iran. Electronic address: f.jalilian@umsha.ac.ir.
Braz J Infect Dis ; 24(2): 144-149, 2020.
Article em En | MEDLINE | ID: mdl-32243867
In recent years, extreme attention has been focused on the role of human herpesvirus-6 (HHV-6) in multiple sclerosis (MS) pathogenesis. However, the pathogenesis of MS associated with HHV-6 infection remains unknown. In this study, we measured the serum levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and vitamin D levels in MS patients with HHV-6 infection and MS patients without HHV-6 infection. Five hundred sixty (including 300 females and 260 males) MS patients along with 560 healthy subjects were analyzed for HHV-6 seropositivity using enzyme-linked immunosorbent assay (ELISA). Subsequently, we measured the serum levels of MMP-2, MMP-9, and vitamin D levels in MS patients with HHV-6 infection and MS patients without HHV-6 infection by ELISA. About 90.7% of MS patients (508/560) were seropositive for HHV-6, while 82.3% (461/560) of healthy subjects were seropositive for this virus (p = 0.001). Moreover, there was a significant increase in the levels of MMP-2, MMP-9, and lower vitamin D in the serum samples of MS patients when compared with healthy subjects. Additionally, we demonstrated that the MMP-9 levels in seropositive MS patients were significantly higher than seronegative MS patients (p =  0.001). Finally, our results demonstrated that the mean of expanded disability status scale (EDSS) in seropositive MS patients was significantly higher in comparison to seronegative MS patients (p < 0.05). In conclusion, we suggest that the HHV-6 infection may play a role in MS pathogenesis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina D / Infecções por Roseolovirus / Metaloproteinase 2 da Matriz / Metaloproteinase 9 da Matriz / Esclerose Múltipla Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Braz J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Irã País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina D / Infecções por Roseolovirus / Metaloproteinase 2 da Matriz / Metaloproteinase 9 da Matriz / Esclerose Múltipla Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Braz J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Irã País de publicação: Brasil