Your browser doesn't support javascript.
loading
Use of SGLT2 Inhibitors in Older Adults: Scientific Evidence and Practical Aspects.
Custódio, Joaquim Silva; Roriz-Filho, Jarbas; Cavalcanti, Catarina Addobbati Jordão; Martins, Amanda; Salles, João Eduardo Nunes.
Afiliação
  • Custódio JS; Department of Family Health, Medical School of Bahia, Federal University of Bahia, Salvador, BA, Brazil.
  • Roriz-Filho J; Hospital Português, Salvador, BA, Brazil.
  • Cavalcanti CAJ; Department of Clinical Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
  • Martins A; AstraZeneca Brazil, Cotia, SP, Brazil. catarinaaddobbati@hotmail.com.
  • Salles JEN; AstraZeneca Brazil, Cotia, SP, Brazil.
Drugs Aging ; 37(6): 399-409, 2020 06.
Article em En | MEDLINE | ID: mdl-32239461
Diabetes mellitus (DM) is an increasingly prevalent condition that has a significant impact on health systems worldwide, particularly in older people. It is estimated that 30% of people aged > 65 years fulfil the diagnostic criteria for DM, with 90% having type 2 DM (T2DM). Generally, specific guidelines for the treatment of T2DM in older people address in a very limited manner the use of more recent therapies, such as sodium-glucose co-transporter-2 inhibitors (SGLT2i), which have important benefits for older people, such as a low risk of hypoglycemia, reduction of cardiovascular and renal risk, and an insulin-independent mechanism, allowing its use in disease of any duration. The SGLT2i class is well-tolerated, though some caution is also suggested, including adjustment of concomitant therapies, such as insulin and antihypertensives, especially loop diuretics. This review discusses the pathophysiological characteristics of the older patient with T2DM and evaluates the main benefits of and cautions for the use of SGLT2i in this population.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Inibidores do Transportador 2 de Sódio-Glicose / Hipoglicemiantes Tipo de estudo: Guideline Limite: Aged / Humans Idioma: En Revista: Drugs Aging Assunto da revista: GERIATRIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Nova Zelândia
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Inibidores do Transportador 2 de Sódio-Glicose / Hipoglicemiantes Tipo de estudo: Guideline Limite: Aged / Humans Idioma: En Revista: Drugs Aging Assunto da revista: GERIATRIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Nova Zelândia