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Primary hyperparathyroidism in developing world: a systematic review on the changing clinical profile of the disease.
Yadav, Sanjay Kumar; Johri, Goonj; Bichoo, Raouef Ahmed; Jha, Chandan Kumar; Kintu-Luwaga, Ronald; Mishra, Saroj Kanta.
Afiliação
  • Yadav SK; Department of Breast and Endocrine Surgery, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India.
  • Johri G; Department of Endocrine Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
  • Bichoo RA; Department of Endocrine Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
  • Jha CK; Department of General Surgery, AIIMS, Patna, India.
  • Kintu-Luwaga R; Mulago National Referral Hospital, Kampala, Uganda.
  • Mishra SK; Department of Endocrine Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Arch Endocrinol Metab ; 64(2): 105-110, 2020 Apr.
Article em En | MEDLINE | ID: mdl-32236309
While the developed world is focusing on laying guidelines for selecting out cases of Asymptomatic primary hyperparathyroidism (PHPT) for surgical intervention and promoting minimal access surgery, the developing world is observing a change in disease spectrum from advanced symptomatic to lesser degree of symptomatic disease and not many with associated Vitamin D deficiency. Few studies from the developing countries of the world have focused on the changing clinical spectrum of PHPT. Objective of this study is to review the changing profile of PHPT in developing world. A systematic literature search was done in December 2017 focussing on publications from the developing world. All studies pertaining to the epidemiology of PHPT published after 1st January 2000 and published in English language were included for analysis. Most of the studies published from developing countries report a predominance of symptomatic disease (79.6% of all included patients) with musculoskeletal disease present in the majority of patients (52.9%). The combined mean serum total calcium (11.9 ± 1.4 mg/dL), serum PTH (668.6 ± 539 pg/mL), serum alkaline phoshpatase (619 ± 826.9 IU/L) and weight of excised parathyroid glands (4.4 ± 3.8 grams) are much higher than those reported from the western studies. Despite this, we found that there is a distinct trend towards a milder form of disease presentation and biochemical profile noticeable in more recent times. Although there is a striking difference in all aspects of PHPT disease epidemiology, clinical presentation and biochemical profile of developing and developed countries, there is a distinct trend towards a milder form of disease presentation and biochemical profile in more recent times.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hiperparatireoidismo Primário Tipo de estudo: Guideline / Systematic_reviews Limite: Humans Idioma: En Revista: Arch Endocrinol Metab Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Índia País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hiperparatireoidismo Primário Tipo de estudo: Guideline / Systematic_reviews Limite: Humans Idioma: En Revista: Arch Endocrinol Metab Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Índia País de publicação: Brasil