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The role of CACNA1C gene and childhood trauma interaction on bipolar disorder.
Bastos, Clarissa Ribeiro; Tovo-Rodrigues, Luciana; Ardais, Ana Paula; Xavier, Janaina; Salerno, Pamela Silva Vitória; Camerini, Laísa; Jansen, Karen; de Mattos Souza, Luciano Dias; da Silva, Ricardo Azevedo; Lara, Diogo Rizzato; Ghisleni, Gabriele.
Afiliação
  • Bastos CR; Laboratory of Clinical Neuroscience, Post-graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
  • Tovo-Rodrigues L; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
  • Ardais AP; Laboratory of Clinical Neuroscience, Post-graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
  • Xavier J; Laboratory of Clinical Neuroscience, Post-graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
  • Salerno PSV; Laboratory of Clinical Neuroscience, Post-graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
  • Camerini L; Laboratory of Clinical Neuroscience, Post-graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
  • Jansen K; Laboratory of Clinical Neuroscience, Post-graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
  • de Mattos Souza LD; Laboratory of Clinical Neuroscience, Post-graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
  • da Silva RA; Laboratory of Clinical Neuroscience, Post-graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
  • Lara DR; Department of Cellular and Molecular Biology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
  • Ghisleni G; Laboratory of Clinical Neuroscience, Post-graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil. Electronic address: gabriele.ghisleni@ucpel.edu.br.
Prog Neuropsychopharmacol Biol Psychiatry ; 101: 109915, 2020 07 13.
Article em En | MEDLINE | ID: mdl-32169562
Studies on gene x environment interaction (GxE) have provided vital information for uncovering the origins of complex diseases. When considering the etiology of bipolar disorder (BD), the role of such interactions is unknown. Here, we tested whether trauma during childhood could modify the effect of two polymorphisms in the CACNA1C gene (rs1006737 and rs4765913) in terms of susceptibility to BD. The study enrolled 878 Caucasian young adults in a cross-sectional population-based survey. BD diagnosis was performed using a clinical interview MINI 5.0, and trauma was assessed with the childhood trauma questionnaire (CTQ). Binary logistic regression models were employed to test the main effects of polymorphisms, haplotypes, and GxE interactions using sex as a confounder. We did not observe an association between the polymorphisms and diagnosis of BD. However, we noted that childhood trauma modified the effect of the rs4765913 polymorphism (p = .018) and the AA haplotype (rs1006737 - rs4765913) (p = .018) on BD susceptibility. A allele carriers of the rs4765913 polymorphism or the AA haplotype exposed to childhood trauma are more likely to develop BD compared to the individuals without a genetic risk. Thus, this study showed that the risk of developing BD in individuals exposed to childhood trauma was influenced by the individual's genetic background, varying according to the CACNA1C genotypes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Canais de Cálcio Tipo L / Polimorfismo de Nucleotídeo Único / Experiências Adversas da Infância Tipo de estudo: Observational_studies / Prevalence_studies / Qualitative_research / Risk_factors_studies Limite: Adult / Child / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Canais de Cálcio Tipo L / Polimorfismo de Nucleotídeo Único / Experiências Adversas da Infância Tipo de estudo: Observational_studies / Prevalence_studies / Qualitative_research / Risk_factors_studies Limite: Adult / Child / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido