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Acetylcholinesterase: The "Hub" for Neurodegenerative Diseases and Chemical Weapons Convention.
Cavalcante, Samir F de A; Simas, Alessandro B C; Barcellos, Marcos C; de Oliveira, Victor G M; Sousa, Roberto B; Cabral, Paulo A de M; Kuca, Kamil; França, Tanos C C.
Afiliação
  • Cavalcante SFA; Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN), Brazilian Army Technological Center (CTEx), Avenida das Américas 28705, Rio de Janeiro 23020-470, Brazil.
  • Simas ABC; Walter Mors Institute of Research on Natural Products (IPPN), Federal University of Rio de Janeiro (UFRJ), CCS, Bloco H, Rio de Janeiro 21941-902, Brazil.
  • Barcellos MC; Department of Chemistry, Faculty of Science, University of Hradec Králové, Rokitanskeho 62, 50003 Hradec Králové, Czech Republic.
  • de Oliveira VGM; Walter Mors Institute of Research on Natural Products (IPPN), Federal University of Rio de Janeiro (UFRJ), CCS, Bloco H, Rio de Janeiro 21941-902, Brazil.
  • Sousa RB; Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN), Brazilian Army Technological Center (CTEx), Avenida das Américas 28705, Rio de Janeiro 23020-470, Brazil.
  • Cabral PAM; Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN), Brazilian Army Technological Center (CTEx), Avenida das Américas 28705, Rio de Janeiro 23020-470, Brazil.
  • Kuca K; Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN), Brazilian Army Technological Center (CTEx), Avenida das Américas 28705, Rio de Janeiro 23020-470, Brazil.
  • França TCC; Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN), Brazilian Army Technological Center (CTEx), Avenida das Américas 28705, Rio de Janeiro 23020-470, Brazil.
Biomolecules ; 10(3)2020 03 07.
Article em En | MEDLINE | ID: mdl-32155996
This article describes acetylcholinesterase (AChE), an enzyme involved in parasympathetic neurotransmission, its activity, and how its inhibition can be pharmacologically useful for treating dementia, caused by Alzheimer's disease, or as a warfare method due to the action of nerve agents. The chemical concepts related to the irreversible inhibition of AChE, its reactivation, and aging are discussed, along with a relationship to the current international legislation on chemical weapons.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Envelhecimento / Guerra Química / Inibidores da Colinesterase / Doença de Alzheimer / Agentes Neurotóxicos Limite: Humans Idioma: En Revista: Biomolecules Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Envelhecimento / Guerra Química / Inibidores da Colinesterase / Doença de Alzheimer / Agentes Neurotóxicos Limite: Humans Idioma: En Revista: Biomolecules Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça