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Hepatitis E infection is an infrequent cause of acute hepatitis in the metropolitan area of Buenos Aires.
Mendizabal, Manuel; Haddad, Leila; Marciano, Sebastián; Ganem, Federico Orozco; Paz, Silvina; Gruz, Fernando; Ridruejo, Ezequiel; Lurbet, María Fernanda; Fernandez, Nora; Descalzi, Valeria; Anders, Margarita; Gadano, Adrián; Martínez, Alfredo; Silva, Y Marcelo.
Afiliação
  • Mendizabal M; Unidad de Hígado y Trasplante Hepático, Hospital Universitario Austral, Pilar, Argentina; Latin American Liver Research, Educational and Awareness Network (LALREAN). Electronic address: mmendiza@cas.austral.edu.ar.
  • Haddad L; Sección Hepatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
  • Marciano S; Sección Hepatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Departamento de Investigación, Hospital Italiano de Buenos Aires, Argentina.
  • Ganem FO; Unidad de Hígado y Trasplante Hepático, Hospital Alemán, Buenos Aires, Argentina.
  • Paz S; Unidad de Hígado, Hospital Británico, Buenos Aires, Argentina.
  • Gruz F; Hospital Italiano de La Plata, Buenos Aires, Argentina.
  • Ridruejo E; Unidad de Hígado y Trasplante Hepático, Hospital Universitario Austral, Pilar, Argentina; Latin American Liver Research, Educational and Awareness Network (LALREAN); Sección Hepatología, Centro de Educación Médica e Investigaciones Clínicas "CEMIC", Buenos Aires, Argentina.
  • Lurbet MF; Sección Hepatología, Centro de Educación Médica e Investigaciones Clínicas "CEMIC", Buenos Aires, Argentina.
  • Fernandez N; Latin American Liver Research, Educational and Awareness Network (LALREAN); Unidad de Hígado, Hospital Británico, Buenos Aires, Argentina.
  • Descalzi V; Latin American Liver Research, Educational and Awareness Network (LALREAN); Unidad de Hígado y Trasplante Hepático, Fundación Favaloro, Buenos Aires, Argentina.
  • Anders M; Latin American Liver Research, Educational and Awareness Network (LALREAN); Unidad de Hígado y Trasplante Hepático, Hospital Alemán, Buenos Aires, Argentina.
  • Gadano A; Sección Hepatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Departamento de Investigación, Hospital Italiano de Buenos Aires, Argentina.
  • Martínez A; Laboratorio de Virología, Centro de Educación Médica e Investigaciones Clínicas "CEMIC", Buenos Aires, Argentina.
  • Silva YM; Unidad de Hígado y Trasplante Hepático, Hospital Universitario Austral, Pilar, Argentina; Latin American Liver Research, Educational and Awareness Network (LALREAN).
J Clin Virol ; 126: 104309, 2020 05.
Article em En | MEDLINE | ID: mdl-32155452
Background Argentina is considered a region of low seroprevalence of hepatitis E virus (HEV), however; no studies have evaluated its burden among acute hepatitis cases. OBJECTIVES: We aimed to estimate the proportion of acute HEV and outcome in a cohort of patients with acute hepatitis from 6 liver units in the Metropolitan area of Buenos Aires (MABA). STUDY DESIGN: We performed a prospective cohort study including patients ≥18 years with acute hepatitis (increase in transaminases x 5 ULN) fromJuly 2016 to May 2018. Severe hepatitis was defined as acute hepatitis + INR> 1.5 and acute liver failure as severe hepatitis + encephalopathy. In patients in whom other etiologies were excluded, HEV tests were performed: anti-HEV IgM/G and HEV-RNA in serum and feces. RESULTS: Overall, 268 patients with acute hepatitis were included in the study. The most frequent etiologies of acute hepatitis were hepatitis B (67patients, 25 %), hepatotoxicity (65, 24 %) and autoimmune hepatitis (26, 10 %). Acute HEV infection was confirmed in 8 (2.98 %; 95 %CI 1.25-5.63) patients who tested positive for anti-HEV IgM. A total of 63 (23.5 %) patients were hospitalized and 9 (3.3 %) patients died. Overall, 48 (18 %) patients developed severe hepatitis, 6 (2.2 %) have acute liver failure, 6 (1.9 %) underwent liver transplantation and 9 (3.4 %) patients died. CONCLUSIONS: the proportion of acute HEV in MABA was low during the period studied. We believe our findings will aid physicians prioritize other etiologies of acute hepatitis over HEV in order to optimize diagnostic resources and offer better care to their patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Anti-Hepatite / Hepatite E / Falência Hepática Aguda / Hepatite Viral Humana Tipo de estudo: Clinical_trials / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Argentina Idioma: En Revista: J Clin Virol Assunto da revista: VIROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Anti-Hepatite / Hepatite E / Falência Hepática Aguda / Hepatite Viral Humana Tipo de estudo: Clinical_trials / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Argentina Idioma: En Revista: J Clin Virol Assunto da revista: VIROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de publicação: Holanda