Mechanisms of the contractile responses to morphine of the mouse colon in vitro.

Contreras, E; Fernández, E; Villar, M

Contreras, E; Fernández, E; Villar, M.

Afiliação

Contreras E; Departamento de Ciencias Fisiológicas (Farmacología), Facultad de Ciencias Biológicas y de Recursos Naturales, Universidad de Concepción, Chile.

Gen Pharmacol ; 19(5): 669-72, 1988.

Article em En | MEDLINE | ID: mdl-3215478

RESUMO

1. Morphine induced a contractile response in the mouse colon which consisted of two phases or components. 2. The first component was dose-related and was inhibited by tetrodotoxin, atropine and naloxone, but was insensible to hexamethonium, propranolol, phentolamine, diphenhydramine and methysergide. 3. The second component of the contractile effect was not modified by atropine, hexamethonium, propranolol, phentolamine, guanethidine or diphenhydramine, but was antagonized by naloxone, tetrodotoxin and serotonin antagonists. 4. Tachyphylaxis was observed only for the first component of the morphine induced contractile response of the mouse colon.

Assuntos

Morfina/farmacologia; Músculo Liso/efeitos dos fármacos; Animais; Colo/efeitos dos fármacos; Técnicas In Vitro; Metadona/farmacologia; Camundongos; Dependência de Morfina/fisiopatologia; Contração Muscular/efeitos dos fármacos; Nalorfina/farmacologia; Naloxona/farmacologia; Neostigmina/farmacologia; Antagonistas da Serotonina/farmacologia

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Morfina / Músculo Liso Limite: Animals Idioma: En Revista: Gen Pharmacol Ano de publicação: 1988 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido

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