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The relationship between urinary C-Telopeptide fragments of type II collagen, knee joint load, pain, and physical function in individuals with medial knee osteoarthritis.
Selistre, Luiz Fernando Approbato; Gonçalves, Glaucia Helena; Vasilceac, Fernando Augusto; Serrão, Paula Regina Mendes da Silva; Nakagawa, Theresa Helissa; Petrella, Marina; Jones, Richard Keith; Mattiello, Stela Márcia.
Afiliação
  • Selistre LFA; Department of Physical Therapy, Universidade Federal de São Carlos (UFSCar), São Carlos, SP, Brazil. Electronic address: lfaselistre@gmail.com.
  • Gonçalves GH; Department of Physical Therapy, Universidade Federal de São Carlos (UFSCar), São Carlos, SP, Brazil.
  • Vasilceac FA; Department of Physical Therapy, Universidade Federal de São Carlos (UFSCar), São Carlos, SP, Brazil.
  • Serrão PRMDS; Department of Physical Therapy, Universidade Federal de São Carlos (UFSCar), São Carlos, SP, Brazil.
  • Nakagawa TH; Department of Physical Therapy, Universidade Federal de São Carlos (UFSCar), São Carlos, SP, Brazil.
  • Petrella M; Department of Physical Therapy, Universidade Federal de São Carlos (UFSCar), São Carlos, SP, Brazil.
  • Jones RK; School of Health Sciences, University of Salford, Salford, United Kingdom.
  • Mattiello SM; Department of Physical Therapy, Universidade Federal de São Carlos (UFSCar), São Carlos, SP, Brazil.
Braz J Phys Ther ; 25(1): 62-69, 2021.
Article em En | MEDLINE | ID: mdl-32151525
OBJECTIVE: Considering the osteoarthritis (OA) model that integrates the biological, mechanical, and structural components of the disease, the present study aimed to investigate the association between urinary C-Telopeptide fragments of type II collagen (uCTX-II), knee joint moments, pain, and physical function in individuals with medial knee OA. METHODS: Twenty-five subjects radiographically diagnosed with knee OA were recruited. Participants were evaluated through three-dimensional gait analysis, uCTX-II level, the WOMAC pain and physical function scores, and the 40m walk test. The association between these variables was investigated using Pearson's product-moment correlation, followed by a hierarchical linear regression, controlled by OA severity and body mass index (BMI). RESULTS: No relationship was found between uCTX-II level and knee moments. A significant correlation between uCTX-II level and pain, physical function, and the 40m walk test was found. The hierarchical linear regression controlling for OA severity and BMI showed that uCTX-II level explained 9% of the WOMAC pain score, 27% of the WOMAC physical function score, and 7% of the 40m walk test. CONCLUSION: Greater uCTX-II level is associated with higher pain and reduced physical function and 40m walk test performance in individuals with medial knee OA.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Peptídeos / Osteoartrite do Joelho / Colágeno Tipo I / Colágeno Tipo II / Articulação do Joelho Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Braz J Phys Ther Assunto da revista: MEDICINA FISICA / REABILITACAO Ano de publicação: 2021 Tipo de documento: Article País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Peptídeos / Osteoartrite do Joelho / Colágeno Tipo I / Colágeno Tipo II / Articulação do Joelho Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Braz J Phys Ther Assunto da revista: MEDICINA FISICA / REABILITACAO Ano de publicação: 2021 Tipo de documento: Article País de publicação: Brasil