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Phonophoretic application of a glucosamine and chondroitin nanoemulsion for treatment of knee chondropathies.
Leite, Cláudia Bs; Coelho, Janaina M; Ferreira-Nunes, Ricardo; Gelfuso, Guilherme M; Durigan, João Lq; Azevedo, Ricardo B; Muehlmann, Luis A; Sousa, Marcelo H.
Afiliação
  • Leite CB; Green Nanotechnology Group, Faculty of Ceilandia, University of Brasilia, Brasilia, DF 72220-900, Brazil.
  • Coelho JM; Laboratory of Nanoscience & Immunology, Faculty of Ceilandia, University of Brasilia, Brasilia, DF 72220-900, Brazil.
  • Ferreira-Nunes R; Department of Genetics & Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia, DF 70910-900, Brazil.
  • Gelfuso GM; Laboratory of Food, Drugs & Cosmetics (LTMAC), University of Brasilia, Brasilia, DF, 70910-900, Brazil.
  • Durigan JL; Laboratory of Food, Drugs & Cosmetics (LTMAC), University of Brasilia, Brasilia, DF, 70910-900, Brazil.
  • Azevedo RB; Rehabilitation Sciences Graduation Program, University of Brasilia, Brasilia, DF 72220-900, Brazil.
  • Muehlmann LA; Department of Genetics & Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia, DF 70910-900, Brazil.
  • Sousa MH; Laboratory of Nanoscience & Immunology, Faculty of Ceilandia, University of Brasilia, Brasilia, DF 72220-900, Brazil.
Nanomedicine (Lond) ; 15(7): 647-659, 2020 03.
Article em En | MEDLINE | ID: mdl-32118508
Aim: This study was performed to assess the effect of the phonophoretic application of a nanoemulsion incorporating glucosamine and chondroitin sulfate (NANO-CG) associated with kinesiotherapy on the reduction of pain and stiffness in knee chondropathy. Materials & methods: NANO-CG was tested in vitro and in vivo prior to being applied in a randomized and controlled clinical trial. Results: Cell viability and hen's egg test-chorionallantonic membrane tests indicated the NANO-CG is safe for topical application. Permeation tests showed NANO-CG enhances drug permeation through the skin. There was no statistical significance between treated groups in this preliminary study, however, pain reduction and complete recovery of articular cartilage were observed in some patients treated with NANO-CG. Conclusion: We demonstrate that NANO-CG may be a promising candidate for the therapy of knee chondropathy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cartilagem Articular / Sulfatos de Condroitina / Osteoartrite do Joelho / Glucosamina Tipo de estudo: Clinical_trials Limite: Animals / Humans Idioma: En Revista: Nanomedicine (Lond) Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cartilagem Articular / Sulfatos de Condroitina / Osteoartrite do Joelho / Glucosamina Tipo de estudo: Clinical_trials Limite: Animals / Humans Idioma: En Revista: Nanomedicine (Lond) Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido