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Evaluation of cytotoxicity of nanolipid carriers with structured Buriti oil in the Caco-2 and HepG2 cell lines.
Reis, Lívia Viana de Castro; Leão, Karina Magna Macena; Ribeiro, Ana Paula Badan; de Jesus, Marcelo Bispo; Macedo, Gabriela Alves; Macedo, Juliana Alves.
Afiliação
  • Reis LVC; Department of Food and Nutrition, Faculty of Food Engineering, University of Campinas, 80, Rua Monteiro Lobato, Campinas, SP, 13083-970, Brazil. liviavcreis@yahoo.com.br.
  • Leão KMM; Department of Food and Nutrition, Faculty of Food Engineering, University of Campinas, 80, Rua Monteiro Lobato, Campinas, SP, 13083-970, Brazil.
  • Ribeiro APB; Department of Food Technology, Faculty of Food Engineering, University of Campinas, 80, Rua Monteiro Lobato, Campinas, SP, 13083-970, Brazil.
  • de Jesus MB; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, 255, Rua Monteiro Lobato, Campinas, SP, 13083-970, Brazil.
  • Macedo GA; Department of Food and Nutrition, Faculty of Food Engineering, University of Campinas, 80, Rua Monteiro Lobato, Campinas, SP, 13083-970, Brazil.
  • Macedo JA; Department of Food and Nutrition, Faculty of Food Engineering, University of Campinas, 80, Rua Monteiro Lobato, Campinas, SP, 13083-970, Brazil. jumacedo@gmail.com.
Bioprocess Biosyst Eng ; 43(6): 1105-1118, 2020 Jun.
Article em En | MEDLINE | ID: mdl-32076836
Buriti oil is rich in monounsaturated fatty acids, carotenoids and tocopherols and it is used for the treatment of various diseases. One strategy to restructure the triglycerides is enzymatic interesterification and nanocarriers have been employed to improve the solubility, bioavailability and stability of active compounds. This work aims to investigate the in vitro cytotoxicity of this structured oil in nanoemulsions and nanostructured lipid carriers to expand the applicability of the crude oil. None of the samples had a cytotoxic effect on Caco-2 and HepG2 cell lines at the concentrations tested. Structured lipids acted protecting against oxidative stress and lipid peroxidation. Additionally, no consumption of glutathione has been observed in both cells, and the compounds present in buriti oil are possibly acting as antioxidants. Thus, nanoparticles prepared with interesterified buriti oil had low cytotoxicity and high oxidative stability, with great potential for future applications.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óleos de Plantas / Portadores de Fármacos / Carotenoides / Nanoestruturas Limite: Humans Idioma: En Revista: Bioprocess Biosyst Eng Assunto da revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óleos de Plantas / Portadores de Fármacos / Carotenoides / Nanoestruturas Limite: Humans Idioma: En Revista: Bioprocess Biosyst Eng Assunto da revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha