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Alternatives to Animal Use in Risk Assessment of Mixtures.
Wallace Hayes, A; Muriana, Arantza; Alzualde, Ainhoa; Fernandez, Dania Bacardi; Iskandar, Anita; Peitsch, Manuel C; Kuczaj, Arkadiusz; Hoeng, Julia.
Afiliação
  • Wallace Hayes A; University of South Florida College of Public Health, Tampa, FL, USA.
  • Muriana A; Biobide USA, Cambridge, MA, USA.
  • Alzualde A; Biobide Spain, San Sebastian, Spain.
  • Fernandez DB; Center for Genetic Engineering and Biotechnology, Havana, Cuba.
  • Iskandar A; Philip Morris International R&D, Philip Morris Products S.A., Neuchâtel, Switzerland.
  • Peitsch MC; Philip Morris International R&D, Philip Morris Products S.A., Neuchâtel, Switzerland.
  • Kuczaj A; Philip Morris International R&D, Philip Morris Products S.A., Neuchâtel, Switzerland.
  • Hoeng J; Philip Morris International R&D, Philip Morris Products S.A., Neuchâtel, Switzerland.
Int J Toxicol ; 39(2): 165-172, 2020.
Article em En | MEDLINE | ID: mdl-32066298
Risk assessment of chemical mixtures has emerged as a focus of research efforts, but traditional toxicology testing in mammals is costly, time-consuming, and subject to ethical scrutiny in the context of recent trends to reduce reliance on animal testing. In this review, which is a summary of presentations given at a workshop in Havana, Cuba, in April 2019, we survey the utility of zebra fish as an alternative laboratory model in whole-mixture and component-based testing, as well as in vitro modeling in 3-dimensional organotypic cultures from primary human cells cultured at the air-liquid interface and organ-on-a-chip platforms. Finally, we discuss the complexities of assessing the dynamics and delivery of multispecies liquid aerosol mixtures along the human respiratory tract, with examples of alternative and computational approaches to aerosol dosimetry. The workshop contributed to the professional development of Cuban toxicologists, an underserved segment of the global scientific community, delivering a set of tools and recommendations that could potentially provide cost-effective solutions for scientists with limited research resources.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medição de Risco / Interações Medicamentosas / Alternativas aos Testes com Animais Tipo de estudo: Etiology_studies / Risk_factors_studies Aspecto: Ethics Limite: Animals / Humans País/Região como assunto: Caribe / Cuba Idioma: En Revista: Int J Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medição de Risco / Interações Medicamentosas / Alternativas aos Testes com Animais Tipo de estudo: Etiology_studies / Risk_factors_studies Aspecto: Ethics Limite: Animals / Humans País/Região como assunto: Caribe / Cuba Idioma: En Revista: Int J Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos