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Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative.
Simpson, Helen Blair; van den Heuvel, Odile A; Miguel, Euripedes C; Reddy, Y C Janardhan; Stein, Dan J; Lewis-Fernández, Roberto; Shavitt, Roseli Gedanke; Lochner, Christine; Pouwels, Petra J W; Narayanawamy, Janardhanan C; Venkatasubramanian, Ganesan; Hezel, Dianne M; Vriend, Chris; Batistuzzo, Marcelo C; Hoexter, Marcelo Q; de Joode, Niels T; Costa, Daniel Lucas; de Mathis, Maria Alice; Sheshachala, Karthik; Narayan, Madhuri; van Balkom, Anton J L M; Batelaan, Neeltje M; Venkataram, Shivakumar; Cherian, Anish; Marincowitz, Clara; Pannekoek, Nienke; Stovezky, Yael R; Mare, Karen; Liu, Feng; Otaduy, Maria Concepcion Garcia; Pastorello, Bruno; Rao, Rashmi; Katechis, Martha; Van Meter, Page; Wall, Melanie.
Afiliação
  • Simpson HB; Columbia University Irving Medical Center, Columbia University, New York, NY, 10032, USA.
  • van den Heuvel OA; The New York State Psychiatric Institute, New York, NY, 10032, USA.
  • Miguel EC; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, de Boelelaan 1117, Amsterdam, Netherlands.
  • Reddy YCJ; Department of Anatomy and Neuroscience, Amsterdam UMC, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, de Boelelaan 1117, Amsterdam, Netherlands.
  • Stein DJ; Obsessive-Compulsive Spectrum Disorders Program, Institute & Department of Psychiatry, Hospital das Clinicas-HCFMUSP, University of Sao Paulo Medical School, Sao Paulo, Brazil.
  • Lewis-Fernández R; National Institute of Developmental Psychiatry, Sao Paulo, Brazil.
  • Shavitt RG; National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India.
  • Lochner C; SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
  • Pouwels PJW; Columbia University Irving Medical Center, Columbia University, New York, NY, 10032, USA.
  • Narayanawamy JC; The New York State Psychiatric Institute, New York, NY, 10032, USA.
  • Venkatasubramanian G; Obsessive-Compulsive Spectrum Disorders Program, Institute & Department of Psychiatry, Hospital das Clinicas-HCFMUSP, University of Sao Paulo Medical School, Sao Paulo, Brazil.
  • Hezel DM; National Institute of Developmental Psychiatry, Sao Paulo, Brazil.
  • Vriend C; SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
  • Batistuzzo MC; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, de Boelelaan 1117, Amsterdam, Netherlands.
  • Hoexter MQ; National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India.
  • de Joode NT; National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India.
  • Costa DL; Columbia University Irving Medical Center, Columbia University, New York, NY, 10032, USA. dianne.hezel@nyspi.columbia.edu.
  • de Mathis MA; The New York State Psychiatric Institute, New York, NY, 10032, USA. dianne.hezel@nyspi.columbia.edu.
  • Sheshachala K; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, de Boelelaan 1117, Amsterdam, Netherlands.
  • Narayan M; Department of Anatomy and Neuroscience, Amsterdam UMC, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, de Boelelaan 1117, Amsterdam, Netherlands.
  • van Balkom AJLM; Obsessive-Compulsive Spectrum Disorders Program, Institute & Department of Psychiatry, Hospital das Clinicas-HCFMUSP, University of Sao Paulo Medical School, Sao Paulo, Brazil.
  • Batelaan NM; National Institute of Developmental Psychiatry, Sao Paulo, Brazil.
  • Venkataram S; Obsessive-Compulsive Spectrum Disorders Program, Institute & Department of Psychiatry, Hospital das Clinicas-HCFMUSP, University of Sao Paulo Medical School, Sao Paulo, Brazil.
  • Cherian A; National Institute of Developmental Psychiatry, Sao Paulo, Brazil.
  • Marincowitz C; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, de Boelelaan 1117, Amsterdam, Netherlands.
  • Pannekoek N; Department of Anatomy and Neuroscience, Amsterdam UMC, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, de Boelelaan 1117, Amsterdam, Netherlands.
  • Stovezky YR; Obsessive-Compulsive Spectrum Disorders Program, Institute & Department of Psychiatry, Hospital das Clinicas-HCFMUSP, University of Sao Paulo Medical School, Sao Paulo, Brazil.
  • Mare K; National Institute of Developmental Psychiatry, Sao Paulo, Brazil.
  • Liu F; Obsessive-Compulsive Spectrum Disorders Program, Institute & Department of Psychiatry, Hospital das Clinicas-HCFMUSP, University of Sao Paulo Medical School, Sao Paulo, Brazil.
  • Otaduy MCG; National Institute of Developmental Psychiatry, Sao Paulo, Brazil.
  • Pastorello B; National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India.
  • Rao R; National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India.
  • Katechis M; Amsterdam UMC, Vrije Universiteit, Psychiatry, Amsterdam Public Health Research Institute, de Boelelaan 1117, Amsterdam, Netherlands.
  • Van Meter P; GGZ inGeest, Specialised Mental Health Care, Amsterdam, The Netherlands.
  • Wall M; Amsterdam UMC, Vrije Universiteit, Psychiatry, Amsterdam Public Health Research Institute, de Boelelaan 1117, Amsterdam, Netherlands.
BMC Psychiatry ; 20(1): 68, 2020 02 14.
Article em En | MEDLINE | ID: mdl-32059696
BACKGROUND: Obsessive-compulsive disorder (OCD) has a lifetime prevalence of 2-3% and is a leading cause of global disability. Brain circuit abnormalities in individuals with OCD have been identified, but important knowledge gaps remain. The goal of the new global initiative described in this paper is to identify robust and reproducible brain signatures of measurable behaviors and clinical symptoms that are common in individuals with OCD. A global approach was chosen to accelerate discovery, to increase rigor and transparency, and to ensure generalizability of results. METHODS: We will study 250 medication-free adults with OCD, 100 unaffected adult siblings of individuals with OCD, and 250 healthy control subjects at five expert research sites across five countries (Brazil, India, Netherlands, South Africa, and the U.S.). All participants will receive clinical evaluation, neurocognitive assessment, and magnetic resonance imaging (MRI). The imaging will examine multiple brain circuits hypothesized to underlie OCD behaviors, focusing on morphometry (T1-weighted MRI), structural connectivity (Diffusion Tensor Imaging), and functional connectivity (resting-state fMRI). In addition to analyzing each imaging modality separately, we will also use multi-modal fusion with machine learning statistical methods in an attempt to derive imaging signatures that distinguish individuals with OCD from unaffected siblings and healthy controls (Aim #1). Then we will examine how these imaging signatures link to behavioral performance on neurocognitive tasks that probe these same circuits as well as to clinical profiles (Aim #2). Finally, we will explore how specific environmental features (childhood trauma, socioeconomic status, and religiosity) moderate these brain-behavior associations. DISCUSSION: Using harmonized methods for data collection and analysis, we will conduct the largest neurocognitive and multimodal-imaging study in medication-free subjects with OCD to date. By recruiting a large, ethno-culturally diverse sample, we will test whether there are robust biosignatures of core OCD features that transcend countries and cultures. If so, future studies can use these brain signatures to reveal trans-diagnostic disease dimensions, chart when these signatures arise during development, and identify treatments that target these circuit abnormalities directly. The long-term goal of this research is to change not only how we conceptualize OCD but also how we diagnose and treat it.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Mapeamento Encefálico / Imageamento por Ressonância Magnética / Estudos Multicêntricos como Assunto / Internacionalidade / Imagem de Tensor de Difusão / Transtorno Obsessivo-Compulsivo Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Região como assunto: Africa / America do norte / America do sul / Asia / Brasil / Europa Idioma: En Revista: BMC Psychiatry Assunto da revista: PSIQUIATRIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Mapeamento Encefálico / Imageamento por Ressonância Magnética / Estudos Multicêntricos como Assunto / Internacionalidade / Imagem de Tensor de Difusão / Transtorno Obsessivo-Compulsivo Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Região como assunto: Africa / America do norte / America do sul / Asia / Brasil / Europa Idioma: En Revista: BMC Psychiatry Assunto da revista: PSIQUIATRIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido