Your browser doesn't support javascript.
loading
Frailty and cognitive decline.
Fabrício, Daiene de Morais; Chagas, Marcos Hortes N; Diniz, Breno S.
Afiliação
  • Fabrício DM; Department of Psychology, Federal University of São Carlos, São Carlos, São Paulo, Brazil.
  • Chagas MHN; Department of Psychology, Federal University of São Carlos, São Carlos, São Paulo, Brazil; Department of Gerontology, Federal University of São Carlos, São Carlos, São Paulo, Brazil.
  • Diniz BS; Adult Neurodevelopment and Geriatric Psychiatry Division, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Platform for Peripheral Biomarkers Discovery, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address: breno.diniz@camh.ca.
Transl Res ; 221: 58-64, 2020 07.
Article em En | MEDLINE | ID: mdl-32045578
Frailty and cognitive impairment are among the 2 most common geriatric syndromes. Their presence poses major risks to the elderly including greater disability, reduced quality of life, and higher morbi-mortality. Recent evidence suggest that frailty can be a risk factor for incident dementia. The opposite is also true since subjects with Alzheimer's disease and other dementia also present with more severe frailty measures. The mechanisms for the association between frailty and cognitive impairment is not clear, but possibly involves abnormalities in biological processes related to aging. Here, we will review the current evidence of the association between frailty and cognitive impairment. We will also review the possible biological mechanistic links between the 2 conditions. Finally, we will address potential therapeutic targets and interventions that can mitigate both conditions.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos Cognitivos / Fragilidade Tipo de estudo: Risk_factors_studies Aspecto: Patient_preference Limite: Humans Idioma: En Revista: Transl Res Assunto da revista: MEDICINA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos Cognitivos / Fragilidade Tipo de estudo: Risk_factors_studies Aspecto: Patient_preference Limite: Humans Idioma: En Revista: Transl Res Assunto da revista: MEDICINA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos