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Metabolomics Approach Expands the Classification of Propolis Samples from Midwest Brazil.
Costa, Alberto G; Yoshida, Nídia C; Garcez, Walmir S; Perdomo, Renata T; Matos, Maria de Fátima C; Garcez, Fernanda R.
Afiliação
  • Costa AG; Institute of Chemistry , Universidade Federal de Mato Grosso do Sul , Campo Grande , MS 79074-460 , Brazil.
  • Yoshida NC; Institute of Chemistry , Universidade Federal de Mato Grosso do Sul , Campo Grande , MS 79074-460 , Brazil.
  • Garcez WS; Institute of Chemistry , Universidade Federal de Mato Grosso do Sul , Campo Grande , MS 79074-460 , Brazil.
  • Perdomo RT; Laboratory of Molecular Biology and Cell Culture, School of Pharmaceutical Sciences, Food Technology, and Nutrition , Universidade Federal de Mato Grosso do Sul , Campo Grande , MS 79070-900 , Brazil.
  • Matos MFC; Laboratory of Molecular Biology and Cell Culture, School of Pharmaceutical Sciences, Food Technology, and Nutrition , Universidade Federal de Mato Grosso do Sul , Campo Grande , MS 79070-900 , Brazil.
  • Garcez FR; Institute of Chemistry , Universidade Federal de Mato Grosso do Sul , Campo Grande , MS 79074-460 , Brazil.
J Nat Prod ; 83(2): 333-343, 2020 02 28.
Article em En | MEDLINE | ID: mdl-32031802
Propolis samples collected from five areas in Mato Grosso do Sul state, Midwest Brazil, comprising portions of the Cerrado, Pantanal, and Atlantic Forest ecosystems, were investigated for metabolomic profiles and evaluated for antioxidant and antitumor potential. Chemical profiles were determined by HPLC-DAD-MS/MS data and evaluated using principal component analysis and hierarchical clustering analysis to discern chemical composition patterns. Based on phytogeographical origin and chemical composition, 20 potential markers were identified and five groups were distinguished: (I) Cerrado/Central, (II) Atlantic Forest/South, (III) Cerrado-Pantanal transition area/Northwest, (IV) Cerrado/North, and (V) Pantanal/West. Drawing on HPLC-DAD-MS/MS and NMR data, 47 compounds were successfully or tentatively identified, including prenylated phenylpropanoids, flavonoids, isoflavonoids, and di- and triterpenoids, among other constituents. Isoflavonoids, typically found in red propolis from Northeast Brazil, are being reported for the first time in a propolis sample from the Midwest. A new prenylated aromatic compound, (E)-3-[4-hydroxy-3-(2-hydroxy-3-methylbut-3-en-1-yl)-5-(3-methylbut-2-en-1-yl)phenyl]propenoic acid, was obtained. Samples in group II exhibited promising antitumor potential against prostate and breast carcinoma cells, as did samples in groups III and IV against the latter cell line. The sample in group I, despite containing the highest amount of total phenolic compounds and being the only sample to exhibit scavenging activity against DPPH, was not the most cytotoxic against the cell lines tested.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Antioxidantes País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Nat Prod Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Antioxidantes País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Nat Prod Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos