Searching for drugs for Chagas disease, leishmaniasis and schistosomiasis: a review.
Int J Antimicrob Agents
; 55(4): 105906, 2020 Apr.
Article
em En
| MEDLINE
| ID: mdl-31987883
Chagas disease, leishmaniasis and schistosomiasis are neglected diseases (NDs) and are a considerable global challenge. Despite the huge number of people infected, NDs do not create interest from pharmaceutical companies because the associated revenue is generally low. Most of the research on these diseases has been conducted in academic institutions. The chemotherapeutic armamentarium for NDs is scarce and inefficient and better drugs are needed. Researchers have found some promising potential drug candidates using medicinal chemistry and computational approaches. Most of these compounds are synthetic but some are from natural sources or are semi-synthetic. Drug repurposing or repositioning has also been greatly stimulated for NDs. This review considers some potential drug candidates and provides details of their design, discovery and activity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquistossomose
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Leishmaniose
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Doença de Chagas
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Descoberta de Drogas
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Reposicionamento de Medicamentos
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Anti-Helmínticos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Int J Antimicrob Agents
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Holanda