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Effect of a family and interdisciplinary intervention to prevent T2D: randomized clinical trial.
Vargas-Ortiz, Katya; Lira-Mendiola, Georgina; Gómez-Navarro, Claudia M; Padilla-Estrada, Katya; Angulo-Romero, Fabiola; Hernández-Márquez, José M; Villa-Martínez, Ana K; González-Mena, Jessica N; Macías-Cervantes, Maciste H; Reyes-Escogido, Maria de Lourdes; Guardado-Mendoza, Rodolfo.
Afiliação
  • Vargas-Ortiz K; Department of Medical Sciences, University of Guanajuato, Campus León, Guanajuato, Mexico.
  • Lira-Mendiola G; Metabolic Research Laboratory, Department of Medicine and Nutrition, University of Guanajuato, Campus León, Blvd. Puente Milenio No. 1001 Fracción del Predio San Carlos C.P. 37670; León, Guanajuato, Mexico.
  • Gómez-Navarro CM; Metabolic Research Laboratory, Department of Medicine and Nutrition, University of Guanajuato, Campus León, Blvd. Puente Milenio No. 1001 Fracción del Predio San Carlos C.P. 37670; León, Guanajuato, Mexico.
  • Padilla-Estrada K; Metabolic Research Laboratory, Department of Medicine and Nutrition, University of Guanajuato, Campus León, Blvd. Puente Milenio No. 1001 Fracción del Predio San Carlos C.P. 37670; León, Guanajuato, Mexico.
  • Angulo-Romero F; Metabolic Research Laboratory, Department of Medicine and Nutrition, University of Guanajuato, Campus León, Blvd. Puente Milenio No. 1001 Fracción del Predio San Carlos C.P. 37670; León, Guanajuato, Mexico.
  • Hernández-Márquez JM; Metabolic Research Laboratory, Department of Medicine and Nutrition, University of Guanajuato, Campus León, Blvd. Puente Milenio No. 1001 Fracción del Predio San Carlos C.P. 37670; León, Guanajuato, Mexico.
  • Villa-Martínez AK; Metabolic Research Laboratory, Department of Medicine and Nutrition, University of Guanajuato, Campus León, Blvd. Puente Milenio No. 1001 Fracción del Predio San Carlos C.P. 37670; León, Guanajuato, Mexico.
  • González-Mena JN; Metabolic Research Laboratory, Department of Medicine and Nutrition, University of Guanajuato, Campus León, Blvd. Puente Milenio No. 1001 Fracción del Predio San Carlos C.P. 37670; León, Guanajuato, Mexico.
  • Macías-Cervantes MH; Department of Medical Sciences, University of Guanajuato, Campus León, Guanajuato, Mexico.
  • Reyes-Escogido ML; Metabolic Research Laboratory, Department of Medicine and Nutrition, University of Guanajuato, Campus León, Blvd. Puente Milenio No. 1001 Fracción del Predio San Carlos C.P. 37670; León, Guanajuato, Mexico.
  • Guardado-Mendoza R; Metabolic Research Laboratory, Department of Medicine and Nutrition, University of Guanajuato, Campus León, Blvd. Puente Milenio No. 1001 Fracción del Predio San Carlos C.P. 37670; León, Guanajuato, Mexico. rguardado@ugto.mx.
BMC Public Health ; 20(1): 97, 2020 Jan 22.
Article em En | MEDLINE | ID: mdl-31969136
BACKGROUND: Lifestyle changes can reduce the risk of T2D; however, no study has evaluated the effect of a lifestyle intervention involving patients´ family. The aim of this study was to compare the impact of an interdisciplinary family (FI) Vs individual intervention (II) on glucose metabolism, insulin resistance (IR), pancreatic ß-cell function and cardiovascular risk markers in patients with prediabetes, as well as to measure the impact on their families' metabolic risk. METHODS: Randomized Clinical Trial (RCT) to compare the impact of FI and II on IR and pancreatic ß-cell function in subjects with prediabetes. There were 122 subjects with prediabetes (and 101 family members) randomized to FI or II. Data were collected in 2015-2016 and analyzed in 2017-2018. FI group had the support of their family members, who also received personalized diet and exercise recommendations; patients and their family members attended monthly a lifestyle enhancement program. II group received personalized diet and exercise recommendations. The follow-up was for 12 months. Glucose, IR, pancreatic ß-cell function and secondary outcomes (body composition and lipid profile) were assessed at baseline, 6 and 12 months. RESULTS: FI group improved area under the glucose curve (AUC) (from 18,597 ± 2611 to 17,237 ± 2792, p = 0.004) and the Matsuda index (from 3.5 ± 2.3 to 4.7 ± 3.5, p = 0.05) at 12 months. II group improved Disposition Index (from 1.5 ± 0.4 to 1.9 ± 0.73, p < .0001) at 12 months. The improvements achieved in weight and lipids at 6 months, were lost in II group at 12 moths, whereas in FI persisted. Adherence up to 12 months was not different between the study groups (FI 56% Vs II 60%). CONCLUSIONS: FI intervention was more effective by improving glucose AUC, insulin sensitivity and lipid profile, besides that, metabolic risk in family members of the FI group was maintained, while the risk of II group was increased. TRIAL REGISTRATION: This study was retrospectively registered at clinicaltrials.gov on December 15, 2015 (NTC026365646).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estado Pré-Diabético / Família / Educação de Pacientes como Assunto / Diabetes Mellitus Tipo 2 / Estilo de Vida Tipo de estudo: Clinical_trials / Etiology_studies / Guideline / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Public Health Assunto da revista: SAUDE PUBLICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estado Pré-Diabético / Família / Educação de Pacientes como Assunto / Diabetes Mellitus Tipo 2 / Estilo de Vida Tipo de estudo: Clinical_trials / Etiology_studies / Guideline / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Public Health Assunto da revista: SAUDE PUBLICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido