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Downsizing Class II Lasso Peptides: Genome Mining-Guided Isolation of Huascopeptin Containing the First Gly1-Asp7 Macrocycle.
Cortés-Albayay, Carlos; Jarmusch, Scott A; Trusch, Franziska; Ebel, Rainer; Andrews, Barbara A; Jaspars, Marcel; Asenjo, Juan A.
Afiliação
  • Cortés-Albayay C; Centre for Biotechnology and Bioengineering, CeBiB, Department of Chemical Engineering, Biotechnology and Materials , University of Chile , Beauchef 851 , Santiago 8370450 , Chile.
  • Jarmusch SA; Marine Biodiscovery Centre, Department of Chemistry , University of Aberdeen , Old Aberdeen AB24 3UE , Scotland, U.K.
  • Trusch F; Institute of Medical Sciences , University of Aberdeen , Foresterhill AB25 2ZD , Scotland, U.K.
  • Ebel R; Division of Plant Sciences, College of Life Science , University of Dundee (at JHI) , Errol Road, Invergowrie , Dundee DD2 5DA , U.K.
  • Andrews BA; Marine Biodiscovery Centre, Department of Chemistry , University of Aberdeen , Old Aberdeen AB24 3UE , Scotland, U.K.
  • Jaspars M; Centre for Biotechnology and Bioengineering, CeBiB, Department of Chemical Engineering, Biotechnology and Materials , University of Chile , Beauchef 851 , Santiago 8370450 , Chile.
  • Asenjo JA; Marine Biodiscovery Centre, Department of Chemistry , University of Aberdeen , Old Aberdeen AB24 3UE , Scotland, U.K.
J Org Chem ; 85(3): 1661-1667, 2020 02 07.
Article em En | MEDLINE | ID: mdl-31931565
A new lasso peptide, huascopeptin, was isolated following genome-mined discovery of a new biosynthetic gene cluster in extremotolerant Streptomyces huasconensis HST28T from Salar de Huasco, Atacama Desert, Chile. Compound 1 is a 13-residue class II lasso peptide containing a novel Gly1-Asp7 macrolactam ring, a three-residue loop, and a three-residue tail, making it the smallest lasso peptide isolated to date. The lasso structure was confirmed using NOE restraint-based molecular dynamics simulations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Streptomyces Idioma: En Revista: J Org Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Chile País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Streptomyces Idioma: En Revista: J Org Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Chile País de publicação: Estados Unidos