Joint selection for two malaria resistance mutations in a south-west Colombian population.

Ortega, Diana Carolina; Cárdenas, Heiber; Barreto, Guillermo

Ortega, Diana Carolina; Cárdenas, Heiber; Barreto, Guillermo.

Afiliação

Ortega DC; Human Molecular Genetics Group, Department of Biology, Universidad del Valle, Cali, Colombia.
Cárdenas H; Human Molecular Genetics Group, Department of Biology, Universidad del Valle, Cali, Colombia.
Barreto G; Human Molecular Genetics Group, Department of Biology, Universidad del Valle, Cali, Colombia. Electronic address: guillermo.barreto@correounivalle.edu.co.

Infect Genet Evol ; 80: 104188, 2020 06.

Article em En | MEDLINE | ID: mdl-31927074

RESUMO

In regions with an Afro-descendant population and where malaria is endemic, high frequencies of polymorphisms have been found that confer resistance to this disease, such as the haemoglobin S (HbS) and Duffy genes, which provide resistance to P. falciparum and P. vivax infection, respectively. The objective of this study was to evaluate the individual and joint selection actions of these two genes in an Afro-descendant Colombian population. A total of 819 individuals were analysed using stratified random sampling. PCR-RFLP and Hardy-Weinberg equilibrium deviation analysis (H-W eq.), linkage disequilibrium (LD), D'IS2 and D'ST2 indexes, neutrality tests, correlations and fitness were performed using Arlequin 3.5.2.2 and R 3.4.1 software. In general, the population showed neutrality and H-W eq. for the HbS gene but not for the Duffy gene (FYA/FYB, FYA/FYBES and FYB/FYBES genotypes were responsible for this deviation). LD between the HbS locus and the promoter region of the Duffy gene, a value D'IS2 = 0.001 and D'ST2 = 0.020 was found, an increase in fitness of the AS*FYBES/FYBES genotype combination (marked in adolescents and adults), and a strong correlation between these genotypes (Rho = 90%, p = .001) were found, evidencing a possible joint selection action for these two alleles. This work presents evidence of the action of natural selection, both individually and jointly, on malaria resistance genes, HbS and Duffy, in the Buenaventura population.

Assuntos

Resistência à Doença/genética; Malária/epidemiologia; Malária/genética; Mutação; Seleção Genética; Alelos; Colômbia/epidemiologia; Estudos Transversais; Sistema do Grupo Sanguíneo Duffy/genética; Frequência do Gene; Aptidão Genética; Genótipo; Hemoglobina Falciforme/genética; Humanos; Desequilíbrio de Ligação; Malária/diagnóstico; Malária/parasitologia; Vigilância da População; Receptores de Superfície Celular/genética

Palavras-chave

Duffy blood-group system; Haemoglobin S; Join selection; Malaria; Natural selection

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Seleção Genética / Resistência à Doença / Malária / Mutação Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies / Screening_studies Limite: Humans País/Região como assunto: America do sul / Colombia Idioma: En Revista: Infect Genet Evol Assunto da revista: BIOLOGIA / DOENCAS TRANSMISSIVEIS / GENETICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Holanda

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