Changes in the contractile activity of the male genital tract as a consequence of vasectomy.
Acta Physiol Pharmacol Latinoam
; 38(2): 159-65, 1988.
Article
em En
| MEDLINE
| ID: mdl-3188959
ABSTRACT
PIP: By means of a video recording system, the contractile muscle activity in the cauda peididymidis and vas deferens of male Wistar rats after vasectomy was studied over time. A rhythmic peristaltic activity was detected in the genital tracts of vasectomized rats as early as 24 hours after the procedure, with a mean frequency of 9.5 contractions/10 minutes. This activity increased progressively in the 1st 30 days after vasectomy and then stabilized as long as 180 days. By 30 days after surgery, all genital tracts exhibited sperm extravasation. The proximal ligated end of the vas deferens was the most common site for granuloma. The contractions were more frequent in genital tracts without granulomas than in those with this complication. When the ductus exhibited excessive distention, there was no contractility in the muscle walls, even when a partial incision was made in the vas deferens to reduce tubal dilatation. This suggests that extreme distention can damage the contractibility of the muscle fibers. Since the advance and return of sperm inside the tubes could facilitate the interaction of sperm with secretions participating in its maturation, the persistent infertility after vasectomy could be related to the contractile alteration that follows the excessive tubal distention. The partial reduction of the high intravasal pressure occurring during sperm extravasation relieves extreme distention of the ductal muscle, suggesting that granuloma formation may prevent damage to the contractile components and reduce the effectiveness of vasectomy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ducto Deferente
/
Vasectomia
/
Epididimo
/
Doenças dos Genitais Masculinos
/
Músculo Liso
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Acta Physiol Pharmacol Latinoam
Assunto da revista:
FARMACOLOGIA
/
FISIOLOGIA
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Argentina