HLA A,B,C and DR association with insulin-dependent diabetes in Martinique.
Tissue Antigens
; 32(1): 1-5, 1988 Jul.
Article
em En
| MEDLINE
| ID: mdl-3187990
HLA-A,B,C, and DR frequencies have been determined in 34 Coloured Martinican IDDM patients to establish the HLA and IDDM associations. HLA A3, B15, B18, Cw3 and DR4 antigens associations with IDDM are confirmed by this study. We found an increase of B21 similar to that found in Asiatic Indians. As in some African Black populations and in Cape coloured people, A1, B8, and DR3 are not increased in our population. We should point out that our patients' ages of onset were low, and that some studies have found DR4 association in young patients and DR3 in older ones. The protective role of DR2 is confirmed here. B35 and Cw4 negative associations have been found. We have observed that the antigens associated with IDDM are decreased in our control population, except DR4, and that the negative associated DR/ and Cw4 antigens are increased compared to the Continental French population. This corresponds with the low IDDM incidence in Blacks and Coloured people.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos HLA-A
/
Antígenos HLA-B
/
Antígenos HLA-C
/
Antígenos HLA-DR
/
Diabetes Mellitus Tipo 1
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
Caribe
/
Martinica
Idioma:
En
Revista:
Tissue Antigens
Ano de publicação:
1988
Tipo de documento:
Article
País de publicação:
Reino Unido