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Data on a genome-wide association study of type 2 diabetes in a Maya population.
Totomoch-Serra, Armando; Domínguez-Cruz, Miriam Givisay; Muñoz, María de Lourdes; García-Escalante, María Guadalupe; Burgueño, Juan; Díaz-Badillo, Álvaro; Valadez-González, Nina; Escalante, Doris Pinto.
Afiliação
  • Totomoch-Serra A; Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados Del Instituto Politécnico Nacional, Mexico City, Mexico.
  • Domínguez-Cruz MG; PhD Program in Medical Sciences, Universidad de La Frontera, Chile.
  • Muñoz ML; Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados Del Instituto Politécnico Nacional, Mexico City, Mexico.
  • García-Escalante MG; Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados Del Instituto Politécnico Nacional, Mexico City, Mexico.
  • Burgueño J; Laboratorios de Genética y Hematología, Centro de Investigaciones Regionales "Dr. Hideyo Noguchi", Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico.
  • Díaz-Badillo Á; Centro Internacional de Mejoramiento de Maíz y Trigo. El Batán, Texcoco, State of Mexico, Mexico.
  • Valadez-González N; Maestría en Salud Publica, Universidad México Americana Del Norte, Reynosa, Tamaulipas, Mexico.
  • Escalante DP; Department of Epidemiology, Human Genetics & Environmental Sciences, The University of Texas Health Science Center at Houston, Brownsville, TX, USA.
Data Brief ; 28: 104866, 2020 Feb.
Article em En | MEDLINE | ID: mdl-31872004
Maya communities have been shown to exhibit type 2 diabetes (T2D) with high prevalence compared with Mexican mestizo populations. Furthermore, some variants associated with the risk for T2D have been described. In this study, we describe the results of a pilot genome wide association study (GWAS) using 817,823 single nucleotide polymorphisms (SNPs) to identify candidate variants for replication in future studies. Herein, we present the GWAS study data, which were divided into three parts: first, 1289 ancestry informative markers (AIMs) were selected for Latino populations containing European, African, and Native American SNPs obtained from the literature; second, a GWAS hypothesis free to select candidate genes associated with T2D was performed, which identified 24 candidate genes; and third, 39 SNPs previously associated with T2D or related traits were replicated. This article is associated with the original article published in "Gene" under the title "Pilot genome-wide association study identifying novel risk loci for type 2 diabetes in a Maya population".
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: Data Brief Ano de publicação: 2020 Tipo de documento: Article País de afiliação: México País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: Data Brief Ano de publicação: 2020 Tipo de documento: Article País de afiliação: México País de publicação: Holanda