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Is one brachytherapy fraction of 7 Gy similar to more fractions after external beam irradiation in postoperative endometrial carcinoma?
Zhang, Y; Ascaso, C; Herreros, A; Sánchez, J; Del Pino, M; Torné, A; Li, Y; Sabater, S; Arenas, M; Biete, A; Rovirosa, Á.
Afiliação
  • Zhang Y; Radiation Oncology Department, Hospital Clinic I Universitari, C/ Villarroel 170, 08036, Barcelona, Spain.
  • Ascaso C; Fonaments Clinics Department, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
  • Herreros A; Fonaments Clinics Department, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
  • Sánchez J; Radiation Oncology Department, Hospital Clinic I Universitari, C/ Villarroel 170, 08036, Barcelona, Spain.
  • Del Pino M; Fonaments Clinics Department, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
  • Torné A; Economics Department, Hospital Clinic I Universitari, Barcelona, Spain.
  • Li Y; Gynecological Cancer Unit, Gynecological and Obstetrics Department, Hospital Clinic I Universitari, Barcelona, Spain.
  • Sabater S; Gynecological Cancer Unit, Gynecological and Obstetrics Department, Hospital Clinic I Universitari, Barcelona, Spain.
  • Arenas M; Radiation Oncology Department, Hospital Clinic I Universitari, C/ Villarroel 170, 08036, Barcelona, Spain.
  • Biete A; Fonaments Clinics Department, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
  • Rovirosa Á; Radiation Oncology Department, Hospital General Universitario de Albacete, Albacete, Spain.
Clin Transl Oncol ; 22(8): 1295-1302, 2020 Aug.
Article em En | MEDLINE | ID: mdl-31865604
PURPOSE: To determine whether brachytherapy with a single hypofractionated dose of 7 Gy provides the similar vaginal-cuff relapses and safety profile in terms of complications compared to schedules of 2 or 3 fractions of lower doses in patients treated previously with external beam irradiation in postoperative endometrial carcinoma. METHODS/MATERIAL: From June 2003 to December 2016, 325 patients were treated with 3 different schedules of high-dose-rate brachytherapy after external beam irradiation for postoperative endometrial carcinoma. The patients were divided into 3 groups: Group-1: 125 patients were treated with 3 fractions of 4-6 Gy per fraction (3 fractions/week) between 2003 and 2008; Group-2: 93 patients were treated with 2 consecutive daily fractions of 5-6 Gy between 2008 and 2011; Group-3: 107 patients received a single fraction of 7 Gy between 2011 and 2016. Bladder and rectum complications were assessed using RTOG scores and with the objective scores of LENT-SOMA for the vagina. STATISTICS: the chi-square test. RESULTS: The mean follow-up of Groups 1, 2 and 3 was 95, 67 and 51 months, respectively. Three patients in Group-1, 2 in Group-2, 1 in Group-3 developed vaginal-cuff relapse (p = 0.68). No differences were found in late toxicity among the three groups. CONCLUSIONS: One single dose of 7 Gy is safe and effective and may be the best treatment schedule with a similar incidence of vaginal-cuff relapses, complications and patient comfort with less hospital attendance.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Braquiterapia / Neoplasias do Endométrio / Fracionamento da Dose de Radiação Tipo de estudo: Etiology_studies Limite: Aged / Female / Humans Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha País de publicação: Itália
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Braquiterapia / Neoplasias do Endométrio / Fracionamento da Dose de Radiação Tipo de estudo: Etiology_studies Limite: Aged / Female / Humans Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha País de publicação: Itália