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Expression of stromal elements of prostatic adenocarcinoma in different gleason scores.
Osorio, Clarice Fraga Esteves Maciel; Costa, Waldemar Silva; Gallo, Carla Braga Mano; Sampaio, Francisco José Barcellos.
Afiliação
  • Osorio CFEM; Fellow PhD degree, Postgraduate Program in Physiopathology and Surgical Sciences, Urogenital Research Unit, Universidade do Estado do Rio de Janeiro (UERJ), Brazil. Conception and design of the study; acquisition, analysis and interpretation of data; technical procedures; histological examinations;
  • Costa WS; PhD, Associate Professor, Urogenital Research Unit, UERJ, Rio de Janeiro-RJ, Brazil. Conception and design of the study, technical procedures, histological examination, interpretation of data, manuscript preparation and writing, final approval.
  • Gallo CBM; PhD, Researcher, Urogenital Research Unit, Rio de Janeiro-RJ, Brazil. Conception and design of the study, interpretation of data, statistics analysis, manuscript preparation and writing, final approval.
  • Sampaio FJB; PhD, Full Professor, Urogenital Research Unit, UERJ, Rio de Janeiro-RJ, Brazil. Conception and design of the study, interpretation of data, critical revision, final approval.
Acta Cir Bras ; 34(10): e201901005, 2019.
Article em En | MEDLINE | ID: mdl-31851213
PURPOSE: To quantify and compare the expression of stromal elements in prostate adenocarcinoma of different Gleason scores with non-tumor area (control). METHODS: We obtained 132 specimens from samples of prostate peripheral and transition zone. We analyzed the following elements of the extracellular matrix: collagen fibers, elastic system, smooth muscle fibers and blood vessels. The tumor area and non-tumor area (control) of the TMA (tissue microarray) were photographed and analyzed using the ImageJ software. RESULTS: The comparison between the tumor area and the non-tumor area showed significant differences between stromal prostate elements. There was an increase of collagen fibers in the tumor area, mainly in Gleason 7. Elastic system fibers showed similar result, also from the Gleason 7. Blood vessels showed a significant increase occurred in all analyzed groups. The muscle fibers exhibited a different behavior, with a decrease in relation to the tumor area. CONCLUSIONS: There is a significant difference between the extracellular matrix in prostate cancer compared to the non-tumor area (control) especially in Gleason 7. Important modifications of the prostatic stromal elements strongly correlate with different Gleason scores and can contribute to predict the pathological staging of prostate cancer.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Adenocarcinoma / Células Estromais Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Acta Cir Bras Ano de publicação: 2019 Tipo de documento: Article País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Adenocarcinoma / Células Estromais Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Acta Cir Bras Ano de publicação: 2019 Tipo de documento: Article País de publicação: Brasil