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Study on the Antinociceptive Activity and Mechanism of Action of Isolated Saponins from Siolmatra brasiliensis (Cogn.) Baill.
Giorno, Thais Biondino Sardella; Santos, Carlos Henrique Corrêa Dos; Carvalho, Mario Geraldo de; Silva, Virgínia Cláudia da; Sousa, Paulo Teixeira de; Fernandes, Patricia Dias; Boylan, Fabio.
Afiliação
  • Giorno TBS; Federal University of Rio de Janeiro, Institute of Biomedical Sciences, Laboratory of Pharmacology of Pain and Inflammation, Rio de Janeiro 21941-902, Brazil.
  • Santos CHCD; Federal University of Rio de Janeiro, Institute of Biomedical Sciences, Graduate Program in Pharmacology and Medicinal Chemistry, Rio de Janeiro 21941-902, Brazil.
  • Carvalho MG; Federal Rural University of Rio de Janeiro, Department of Chemistry, Seropédica 23890-000, Brazil.
  • Silva VCD; Federal Rural University of Rio de Janeiro, Department of Chemistry, Seropédica 23890-000, Brazil.
  • Sousa PT; Federal University of Mato Grosso, Department of Chemistry, Cuiabá 78935-901, Brazil.
  • Fernandes PD; Federal University of Mato Grosso, Department of Chemistry, Cuiabá 78935-901, Brazil.
  • Boylan F; Federal University of Rio de Janeiro, Institute of Biomedical Sciences, Laboratory of Pharmacology of Pain and Inflammation, Rio de Janeiro 21941-902, Brazil.
Molecules ; 24(24)2019 Dec 14.
Article em En | MEDLINE | ID: mdl-31847360
Infusions of roots of Siolmatra brasiliensis (Cogn.) Baill, ("taiuiá", "cipó-tauá") are used for toothache pain and ulcers. We aimed to study the antinociceptive effects and identify the possible mechanism of action of this plant and its isolated substances (cayaponoside A1, cayaponoside B4, cayaponoside D, and siolmatroside I). Hydroethanol extract (HE), ethyl acetate fraction (EtOAc), and isolated saponins were evaluated in chemical and thermal models of pain in mice. Animals were orally pretreated and evaluated in the capsaicin- or glutamate-induced licking and in the hot plate tests. The antinociceptive mechanism of action was evaluated using the hot plate test with the following pretreatments: Atropine (cholinergic antagonist), naloxone (opioid antagonist), or L-NAME (nitric oxide synthase inhibitor). All extracts and isolated saponins increased the area under the curve in the hot plate test. Tested substances induced a higher effect than the morphine-treated group. Our data suggest that stems of S. brasiliensis and their isolated substances present antinociceptive effects. Cholinergic and opioidergic pathways seem to be involved in their mechanism of action. Taken together our data corroborate the traditional use of the plant and expands the information regarding its use.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saponinas / Extratos Vegetais / Cucurbitaceae / Analgésicos Tipo de estudo: Prognostic_studies Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saponinas / Extratos Vegetais / Cucurbitaceae / Analgésicos Tipo de estudo: Prognostic_studies Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça