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Sleep deprivation changes thimet oligopeptidase (THOP1) expression and activity in rat brain.
Visniauskas, Bruna; Simões, Priscila S R; Dalio, Fernanda M; Naffah-Mazzacoratti, Maria D G; Oliveira, Vitor; Tufik, Sergio; Chagas, Jair R.
Afiliação
  • Visniauskas B; Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, 04024-002, Brazil.
  • Simões PSR; Department of Neurology/Neurosurgery, Universidade Federal de São Paulo, São Paulo, 04039-032, Brazil.
  • Dalio FM; Department of Biophysics, Universidade Federal de São Paulo, São Paulo, 04039-032, Brazil.
  • Naffah-Mazzacoratti MDG; Department of Neurology/Neurosurgery, Universidade Federal de São Paulo, São Paulo, 04039-032, Brazil.
  • Oliveira V; Department of Biophysics, Universidade Federal de São Paulo, São Paulo, 04039-032, Brazil.
  • Tufik S; Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, 04024-002, Brazil.
  • Chagas JR; Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, 04024-002, Brazil.
Heliyon ; 5(11): e02896, 2019 Nov.
Article em En | MEDLINE | ID: mdl-31828230
The consequences of sleep deprivation on memory, cognition, nociception, stress, and endocrine function are related to the balance of neuropeptides, with peptidases being particularly essential. Thimet oligopeptidase (THOP1) is a metallopeptidase implicated in the metabolism of many sleep-related peptides, including angiotensin I, gonadotropin releasing hormone (GnRH), neurotensin, and opioid peptides. In the present study, we evaluated the effect of sleep deprivation and sleep recovery in male rats on THOP1 expression and specific activity in the central nervous system. In the striatum and hypothalamus, THOP1 activity decreased following sleep deprivation and a recovery period. Meanwhile, THOP1 activity and immunoexpression increased in the hippocampal dentate gyrus during the sleep recovery period. Changes in THOP1 expression after sleep deprivation and during sleep recovery can potentially alter the processing of neuropeptides. In particular, processing of opioid peptides may be related to the known increase in pain sensitivity in this model. These results suggest that THOP1 may be an important player in the effects of sleep deprivation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Heliyon Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Heliyon Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido