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Detection and Whole-Genome Analysis of a High-Risk Clone of Klebsiella pneumoniae ST340/CG258 Producing CTX-M-15 in a Companion Animal.
Valencia-Bacca, Juan; Silva, Meire M; Cerdeira, Louise; Esposito, Fernanda; Cardoso, Brenda; Muñoz, Maria E; Jiménez-Villegas, Tatiana; Cardenas-Arias, Adriana; Pessoa, Danielle A N; Lincopan, Nilton.
Afiliação
  • Valencia-Bacca J; Department of Preventive Veterinary Medicine and Animal Health, Universidade de São Paulo, São Paulo, Brazil.
  • Silva MM; Veterinary Medicine Academic Unit, University Center of João Pessoa, Paraíba, Brazil.
  • Cerdeira L; School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
  • Esposito F; School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
  • Cardoso B; Department of Microbiology, Institute of Biomedical Sciences, Universidade de São Paulo, São Paulo, Brazil.
  • Muñoz ME; School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
  • Jiménez-Villegas T; Department of Preventive Veterinary Medicine and Animal Health, Universidade de São Paulo, São Paulo, Brazil.
  • Cardenas-Arias A; Department of Microbiology, Institute of Biomedical Sciences, Universidade de São Paulo, São Paulo, Brazil.
  • Pessoa DAN; School of Veterinary Medicine, Federal University of Campina Grande, Paraíba, Brazil.
  • Lincopan N; School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Microb Drug Resist ; 26(6): 611-615, 2020 Jun.
Article em En | MEDLINE | ID: mdl-31809242
The emergence and dissemination of high-risk clones of Klebsiella pneumoniae producing extended-spectrum ß-lactamases (ESBLs) in animal infections is a critical issue. We report the detection and genomic features of a multidrug-resistant (MDR) ESBL (CTX-M-15)-producing K. pneumoniae infecting a domestic cat. Whole-genome sequencing analysis identified the international ST340 (clonal group CG258), and genes and mutations conferring resistance to ß-lactams, aminoglycosides, macrolides, phenicols, fosfomycin, sulfonamides, tetracycline, trimethoprim, and fluoroquinolones. In addition, the presence of genes encoding resistance to disinfectant and heavy metals hazardous to humans was also confirmed. The MDR profile exhibited by the strain contributed to treatment failure and death of the companion animal. Therefore, active surveillance of critical priority lineages of K. pneumoniae should not only focus on human infections but also on veterinary infections.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Gatos / Animais de Estimação / Klebsiella pneumoniae / Antibacterianos Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Microb Drug Resist Assunto da revista: MICROBIOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Gatos / Animais de Estimação / Klebsiella pneumoniae / Antibacterianos Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Microb Drug Resist Assunto da revista: MICROBIOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos