Your browser doesn't support javascript.
loading
P2Y6 and P2X7 Receptor Antagonism Exerts Neuroprotective/ Neuroregenerative Effects in an Animal Model of Parkinson's Disease.
Oliveira-Giacomelli, Ágatha; M Albino, Carolina; de Souza, Hellio Danny Nóbrega; Corrêa-Velloso, Juliana; de Jesus Santos, Ana Paula; Baranova, Juliana; Ulrich, Henning.
Afiliação
  • Oliveira-Giacomelli Á; Neuroscience Laboratory, Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
  • M Albino C; Neuroscience Laboratory, Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
  • de Souza HDN; Neuroscience Laboratory, Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
  • Corrêa-Velloso J; Neuroscience Laboratory, Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
  • de Jesus Santos AP; Neuroscience Laboratory, Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
  • Baranova J; Neuroscience Laboratory, Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
  • Ulrich H; Neuroscience Laboratory, Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
Front Cell Neurosci ; 13: 476, 2019.
Article em En | MEDLINE | ID: mdl-31787881
Parkinson's disease (PD) is a neurodegenerative disorder characterized by decreased dopamine bioavailability in the substantia nigra and the striatum. Taking into account that adenosine-5'-triphosphate (ATP) and its metabolites are intensely released in the 6-hydroxydopamine (6-OHDA) animal model of PD, screening of purinergic receptor gene expression was performed. Effects of pharmacological P2Y6 or P2X7 receptor antagonism were studied in preventing or reversing hemiparkinsonian behavior and dopaminergic deficits in this animal model. P2X7 receptor antagonism with Brilliant Blue G (BBG) at a dose of 75 mg/kg re-established the dopaminergic nigrostriatal pathway in rats injured with 6-OHDA. Selective P2Y6 receptor antagonism by MRS2578 prevented dopaminergic neuron death in SH-SY5Y cells in vitro and in vivo in the substantia nigra of rats injured with 6-OHDA. Moreover, in vivo analysis showed that both treatments were accompanied by a reduction of microglial activation in the substantia nigra. Altogether, these data provide evidence that antagonism of P2X7 or P2Y6 receptors results in neuroregenerative or neuroprotective effects, respectively, possibly through modulation of neuroinflammatory responses.
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Cell Neurosci Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Cell Neurosci Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça