Effect of Byrsonima sericea DC. leaf extracts on mice gastrointestinal tract.
Toxicol Rep
; 6: 1182-1187, 2019.
Article
em En
| MEDLINE
| ID: mdl-31763182
Byrsonima sericea DC. (Malpighiaceae) leaves are popularly folk medicine in Brazil used to treat gastro-intestinal disorders including diarrhea and gastric diseases. Ethanol extract (BSEE), ethyl acetate extract (BSEAE) and hexane extract (BSHE) of the leaf part of Byrsonima sericea DC were characterized for their total phenolics, proanthocyanidins and flavonoids content. The total antioxidant capacity of extracts was determined. The ethnopharmacological use of B. sericea leaves was evaluated by assaying BSEE for gastroprotective activity in stomach ulcer induced by indomethacin, intestinal motility and toxicity. Abundance of phenols mainly tannins was found in BSEE. Total phenolics, flavonoids and proanthocyanidins content in BSEE were found to be 0.371, 0.172 and 1.3 × 10-4 (mg/g) respectively. BSEE showed concentration dependent significant scavenging of DPPH values 90.0 (%) respectively. Moreover, oral doses of 500 and 1000 mg/kg did not cause mortality, and there was no difference in animals weight, organs relative weight and alanine transaminase (ALT) and aspartate transaminase (AST), as compared to the control group. Doses of 250, 500 and 1000 mg/kg inhibited the gastric lesions induced by indomethacin in 52, 60 and 62 % respectively. The dose of 1000 mg/kg decreased intestinal motility in animals. The presence of phenolic compounds, including tannins could be associated with the anti-diarrheal action and the antioxidant properties could collaborate to the gastroprotective and anti- diarrheal activities, confirming its popular use of the plant.
ALT, alanine transaminase; ANOVA, one-way analysis of variance; AST, aspartate transaminase; Antioxidants; BSEAE, Byrsonima sericea ethyl acetate extract; BSEE, Byrsonima sericea ethanol extract; BSHE, Byrsonima sericea hexane extract; Byrsonima sericea DC; DMSO, dimethyl sulfoxide; DPPH, 2,2-diphenyl-1- picrylhydrazyl; Gastroprotective; HPLC-DAD, high performance liquid chromatography-diode array detector; Indomethacin; MS, mass spectrometry; NSAIDs, nonsteroidal anti-inflammatory drugs; PGE2, prostaglandin; PI, inhibition potential; SD, standard deviation; Toxicity; im, intra-muscular
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Toxicol Rep
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Irlanda