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Treatment of chronic hepatitis C in patients with chronic kidney disease with Sofosbuvir-basead regimes.
Rossato, Giovana; Tovo, Cristiane Valle; Almeida, Paulo Roberto Lerias de.
Afiliação
  • Rossato G; Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Aelgre, RS, Brazil. Electronic address: giovanadrossato@gmail.com.
  • Tovo CV; Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Aelgre, RS, Brazil. Electronic address: cristianev@ufcspa.edu.br.
  • Almeida PRL; Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Aelgre, RS, Brazil. Electronic address: paulorlalmeida@terra.com.br.
Braz J Infect Dis ; 24(1): 25-29, 2020.
Article em En | MEDLINE | ID: mdl-31760038
BACKGROUND: To analyze the effectiveness and the safety of Sofosbuvir-based regimens to treat patients with chronic hepatitis C virus (HCV) infection and chronic kidney disease (CKD). METHODS: A retrospective, observational study in patients with chronic HCV infection and CKD treated with Sofosbuvir-based regimens was performed. Liver fibrosis, comorbidities, HCV genotype and sustained virological resposnse (SVR) at 12th week post-treatment were evaluated. Kidney function was accessed by serum creatinine and glomerular filtration rate (GFR). The assumed level of significance was 5 %. RESULTS: Thirty-five patients were treated. The mean age was 52.1±10.9 years, 19 (54.3 %) were women, 32 (91.4 %) were already kidney transplanted and 3 (8.6 %) were on hemodialysis. The SVR by intention to treat was 88.6 %. The mean GFR was 65.8±28.6 and 63.7±28.3ml/min pre- and post-treatment respectively (p>0.05). Treatment was interrupted in 1 (2.85 %) patient due to anemia and in 2 (5.7 %) due to loss of kidney function. CONCLUSION: Sofosbuvir-based regimens are effective to treat HCV in patients with CKD. In patients with mild CKD this type of therapy seems to be safe.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Hepatite C Crônica / Insuficiência Renal Crônica / Sofosbuvir Tipo de estudo: Observational_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Braz J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2020 Tipo de documento: Article País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Hepatite C Crônica / Insuficiência Renal Crônica / Sofosbuvir Tipo de estudo: Observational_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Braz J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2020 Tipo de documento: Article País de publicação: Brasil