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Interleukin 1-beta is Linked to Chronic Low-Grade Inflammation and Cardiovascular Risk Factors in Overweight Adolescents.
Amaral, Gisele A; Alves, Josilene D; Honorio-França, Adenilda C; Fagundes, Danny L; Araujo, Gabriel Gomes; Lobato, Nubia S; Lima, Victor V; Giachini, Fernanda R.
Afiliação
  • Amaral GA; Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas, MT, Brazil.
  • Alves JD; UNIVAR ­ Araguaia Valley University Center, Barra do Garças, MT, Brazil
  • Honorio-França AC; Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas, MT, Brazil.
  • Fagundes DL; Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas, MT, Brazil.
  • Araujo GG; Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas, MT, Brazil.
  • Lobato NS; Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas, MT, Brazil.
  • Lima VV; Department of Biological Sciences, Division of Cardiovascular Physiology, Federal University of Goias, Jatai, Brazil
  • Giachini FR; Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas, MT, Brazil.
Endocr Metab Immune Disord Drug Targets ; 20(6): 887-894, 2020.
Article em En | MEDLINE | ID: mdl-31738140
AIM: We hypothesized that IL-1ß concentrations are augmented in overweight adolescents, who do not display metabolic syndrome. Additionally, we aimed to correlate the IL-1ß concentrations with several established risk factors for CVD. METHODS: Overweight or control subjects, aging from 14-18 years, were classified according to their adjusted body mass index and evaluated for biochemical and anthropometric parameters. The proinflammatory cytokine IL-1ß was assessed in the serum. RESULTS: Increased body fat percentage, waist circumference, triglycerides, total cholesterol, Very Low-Density Lipoprotein (VLDL) cholesterol, Low-Density Lipoprotein (LDL) cholesterol, Castelli I index, IL-1ß, and IL-8 levels, were observed in overweight adolescents. No differences were observed in systolic blood pressure, diastolic blood pressure, glucose or High-Density Lipoprotein (HDL) cholesterol. Positive correlations between IL-1ß with anthropometric and or biochemical parameters were found. CONCLUSION: In conclusion, increased IL-1ß levels correlate to dyslipidemic factors and may further support low-grade inflammation. IL-1ß may further predict the early onset of cardiovascular disease in this population, taking into consideration its important regulatory role.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sobrepeso / Interleucina-1beta / Fatores de Risco de Doenças Cardíacas / Inflamação Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Endocr Metab Immune Disord Drug Targets Assunto da revista: ALERGIA E IMUNOLOGIA / ENDOCRINOLOGIA / METABOLISMO / TERAPIA POR MEDICAMENTOS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Emirados Árabes Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sobrepeso / Interleucina-1beta / Fatores de Risco de Doenças Cardíacas / Inflamação Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Endocr Metab Immune Disord Drug Targets Assunto da revista: ALERGIA E IMUNOLOGIA / ENDOCRINOLOGIA / METABOLISMO / TERAPIA POR MEDICAMENTOS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Emirados Árabes Unidos