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Rapid extraction method followed by a d-SPE clean-up step for determination of phenolic composition and antioxidant and antiproliferative activities from berry fruits.
Rodrigues, Carina Alexandra; Nicácio, Antonio Eduardo; Boeing, Joana Schuelter; Garcia, Francielle Pelegrin; Nakamura, Celso Vataru; Visentainer, Jesuí Vergílio; Maldaner, Liane.
Afiliação
  • Rodrigues CA; Chemistry Department, State University of Maringá (UEM), Maringá, PR, Brazil.
  • Nicácio AE; Chemistry Department, State University of Maringá (UEM), Maringá, PR, Brazil.
  • Boeing JS; Chemistry Department, State University of Maringá (UEM), Maringá, PR, Brazil; Faculty of Exact Sciences and Technology (FACET), Federal University of Grande Dourados (UFGD), Dourados, MS, Brazil.
  • Garcia FP; Post-Graduate Program in Biological Sciences, Cellular and Molecular Biological Concentration Area, State University of Maringá (UEM), Maringá, PR, Brazil.
  • Nakamura CV; Post-Graduate Program in Biological Sciences, Cellular and Molecular Biological Concentration Area, State University of Maringá (UEM), Maringá, PR, Brazil; Post-Graduate Program in Pharmaceutical Sciences, State University of Maringá (UEM), Maringá, PR, Brazil.
  • Visentainer JV; Chemistry Department, State University of Maringá (UEM), Maringá, PR, Brazil.
  • Maldaner L; Chemistry Department, State University of Maringá (UEM), Maringá, PR, Brazil. Electronic address: lianemaldaner@gmail.com.
Food Chem ; 309: 125694, 2020 Mar 30.
Article em En | MEDLINE | ID: mdl-31706673
Despite the numerous studies that have shown a wide range of biological activities to berry fruits, scientific data focusing on modern, rapid and simple extraction methods followed by a clean-up step is still lacking. Therefore, the present work was aimed at investigating the use of a fast one-step solid-liquid extraction procedure followed by a dispersive solid-phase extraction (d-SPE) clean-up step to evaluate the phenolic composition, antioxidant and antiproliferative activities from three of the principal berries found in Brazil, pomegranate (Punica granatum L.), blackberry (Rubus ulmifolius Schott.), and strawberry (Fragaria × ananassa Duch.). Under the optimized extraction conditions, sixteen phenolic compounds were determined by UHPLC-MS/MS analysis and all berry extracts showed antioxidant activity and antiproliferative effects on cervical (HeLa) and colon (HT-29) cancer cells. Overall, these results highlight the importance of the clean-up step for more reliable data in studies of health-promoting proprieties from berry fruits.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenóis / Extratos Vegetais / Rosaceae / Proliferação de Células / Antioxidantes Limite: Humans Idioma: En Revista: Food Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenóis / Extratos Vegetais / Rosaceae / Proliferação de Células / Antioxidantes Limite: Humans Idioma: En Revista: Food Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido