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Baccharis trimera (Less.) DC: An Innovative Cardioprotective Herbal Medicine Against Multiple Risk Factors for Cardiovascular Disease.
Souza, Marília Moraes Queiroz; Silva, Gustavo Ratti da; Cola, Itaruã Machri; Silva, Aniely Oliveira; Schaedler, Maysa Isernhagen; Guarnier, Lucas Pires; Palozi, Rhanany Alan Calloi; Barboza, Lorena Neris; Menetrier, Jacqueline Vergutz; Froelich, Diego Lacir; Auth, Pablo Alvarez; Veiga, Alan de Almeida; Souza, Lauro Mera de; Lovato, Evellyn Claudia Wietzikoski; Ribeiro-Paes, João Tadeu; Gasparotto Junior, Arquimedes; Lívero, Francislaine Aparecida Dos Reis.
Afiliação
  • Souza MMQ; Laboratory of Preclinical Research of Natural Products, Postgraduate Program in Medicinal Plants and Phytotherapeutics in Basic Attention, Paranaense University, Umuarama, Paraná, Brazil.
  • Silva GRD; Laboratory of Preclinical Research of Natural Products, Postgraduate Program in Medicinal Plants and Phytotherapeutics in Basic Attention, Paranaense University, Umuarama, Paraná, Brazil.
  • Cola IM; Laboratory of Preclinical Research of Natural Products, Postgraduate Program in Medicinal Plants and Phytotherapeutics in Basic Attention, Paranaense University, Umuarama, Paraná, Brazil.
  • Silva AO; Laboratory of Electrophysiology and Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
  • Schaedler MI; Laboratory of Electrophysiology and Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
  • Guarnier LP; Laboratory of Electrophysiology and Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
  • Palozi RAC; Laboratory of Electrophysiology and Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
  • Barboza LN; Laboratory of Preclinical Research of Natural Products, Postgraduate Program in Medicinal Plants and Phytotherapeutics in Basic Attention, Paranaense University, Umuarama, Paraná, Brazil.
  • Menetrier JV; Laboratory of Preclinical Research of Natural Products, Postgraduate Program in Medicinal Plants and Phytotherapeutics in Basic Attention, Paranaense University, Umuarama, Paraná, Brazil.
  • Froelich DL; Laboratory Prevention and Diagnosis, Assis Gurgacz Faculty, Cascavel, Paraná, Brazil.
  • Auth PA; Laboratory of Preclinical Research of Natural Products, Postgraduate Program in Medicinal Plants and Phytotherapeutics in Basic Attention, Paranaense University, Umuarama, Paraná, Brazil.
  • Veiga AA; Institute of Research Pelé Pequeno Príncipe, Pequeno Príncipe Faculty, Curitiba, Paraná, Brazil.
  • Souza LM; Institute of Research Pelé Pequeno Príncipe, Pequeno Príncipe Faculty, Curitiba, Paraná, Brazil.
  • Lovato ECW; Laboratory of Preclinical Research of Natural Products, Postgraduate Program in Medicinal Plants and Phytotherapeutics in Basic Attention, Paranaense University, Umuarama, Paraná, Brazil.
  • Ribeiro-Paes JT; Laboratory of Genetics and Cell Therapy, São Paulo State University, UNESP, Assis, São Paulo, Brazil.
  • Gasparotto Junior A; Laboratory of Electrophysiology and Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
  • Lívero FADR; Laboratory of Preclinical Research of Natural Products, Postgraduate Program in Medicinal Plants and Phytotherapeutics in Basic Attention, Paranaense University, Umuarama, Paraná, Brazil.
J Med Food ; 23(6): 676-684, 2020 Jun.
Article em En | MEDLINE | ID: mdl-31702422
Cardiovascular disease (CVD) is the leading cause of death worldwide and among its modifiable risk factors are dyslipidemia, diabetes, and smoking. Experimental models evaluated this risk factors singly, however, there is a lack of models that agglomerate these risk factors, resembling real patients and elucidating the pathophysiology of CVD. Moreover, few studies have investigated the cardioprotective effects of Baccharis trimera, a species with lipid-lowering effects. In this study, ethanol-soluble fraction of B. trimera was characterized by liquid chromatography-mass spectrometry. Diabetes was induced by streptozotocin in Wistar rats that also received 0.5% cholesterol-enriched chow and were exposed to the smoke of nine cigarettes, 5 days/week, for 4 weeks. During the last 2 weeks, the animals were treated with vehicle (C-), B. trimera, or simvastatin plus insulin. At the end, cholesterol, triglyceride, urea, and creatinine levels; blood pressure (BP); heart rate (HR); abdominal aortic morphometry; vascular reactivity; renal and cardiac oxidative status; and histopathological changes were evaluated. The agglomerate of risk factors promoted alterations contrary to those described in the literature for the isolated risk factors. The C- group exhibited oxidative stress, increase in biochemical parameters, and thickening of the wall of the abdominal aorta. HR, systolic, diastolic, and mean BP decreased, and vascular reactivity was altered. Cardiac and renal histopathological changes were observed. Treatment with B. trimera reversed these changes and this effect may be partially attributable to lipid-lowering action and to the inhibition of free radical generation. B. trimera has cardioprotective effects in this model, with no toxicity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Doenças Cardiovasculares / Baccharis / Fatores de Risco de Doenças Cardíacas Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Med Food Assunto da revista: CIENCIAS DA NUTRICAO / MEDICINA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Doenças Cardiovasculares / Baccharis / Fatores de Risco de Doenças Cardíacas Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Med Food Assunto da revista: CIENCIAS DA NUTRICAO / MEDICINA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos