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Executive functions and memory in bipolar disorders I and II: new insights from meta-analytic results.
Cotrena, C; Damiani Branco, L; Ponsoni, A; Samamé, C; Milman Shansis, F; Paz Fonseca, R.
Afiliação
  • Cotrena C; Department of Health Science, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
  • Damiani Branco L; Department of Health Science, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
  • Ponsoni A; Department of Health Science, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
  • Samamé C; School of Psychology, University of Buenos Aires, Buenos Aires, Argentina.
  • Milman Shansis F; Faculdade de Medicina da Universidade do Vale dos Sinos (UNISINOS) São Leopoldo, Programa de Pos-Graduação em Saude Coletiva, São Leopoldo, Rio Grande do Sul, Brazil.
  • Paz Fonseca R; Department of Health Science, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Acta Psychiatr Scand ; 141(2): 110-130, 2020 02.
Article em En | MEDLINE | ID: mdl-31697843
OBJECTIVE: To perform a systematic review and meta-analysis of executive functions (EF) and episodic memory in bipolar disorder (BD). METHODS: A literature search was conducted on three electronic databases. Results were combined using random-effects meta-analysis. RESULTS: A total of 126 studies (6424 patients with BDI, 702 with BDII, and 8276 controls) were included. BDI was associated with moderate to large impairments across all cognitive functions and BDII with small-to-medium impairments. Small significant differences were identified between BDI and BDII on all cognitive functions except inhibition. The Trail Making Test (TMT) (g = 0.74, 95% CI: 0.67-0.80), Hayling Test (g = 0.58, 95% CI: 0.34-0.81), Digit Span Total (g = 0.79, 95% CI: 0.57-1.01), and Category Fluency (g = 0.59, 95% CI: 0.45-0.72) tasks were most sensitive to cognitive impairment in BDI. The TMT (g = 0.65, 95% CI: 0.50-0.80) and Category Fluency (g = 0.56, 95% CI: 0.37-0.75) were also sensitive to cognitive alterations in patients with BDII. CONCLUSION: BD type I was associated with more severe and widespread impairments than BDII, which showed smaller impairments on all functions except inhibition, where impairments were larger. Education and (hypo)manic symptoms should be further investigated in future studies due to their possible influence on the neuropsychological profile of BD. The instruments identified in this review should be considered for inclusion in cognitive assessment batteries in BD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Função Executiva / Memória Episódica / Disfunção Cognitiva Tipo de estudo: Systematic_reviews Limite: Humans Idioma: En Revista: Acta Psychiatr Scand Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Função Executiva / Memória Episódica / Disfunção Cognitiva Tipo de estudo: Systematic_reviews Limite: Humans Idioma: En Revista: Acta Psychiatr Scand Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos