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Impact of multi-micronutrient supplementation on lipidemia of children and adolescents.
Chakrabarti, Anirikh; Eiden, Michael; Morin-Rivron, Delphine; Christinat, Nicolas; Monteiro, Jacqueline P; Kaput, Jim; Masoodi, Mojgan.
Afiliação
  • Chakrabarti A; Lipid Metabolism, Nestlé Research, EPFL Innovation Park, 1015, Switzerland.
  • Eiden M; Lipid Metabolism, Nestlé Research, EPFL Innovation Park, 1015, Switzerland; Eidea Bioscience Ltd., Cambridge, United Kingdom.
  • Morin-Rivron D; Lipid Metabolism, Nestlé Research, EPFL Innovation Park, 1015, Switzerland.
  • Christinat N; Lipid Metabolism, Nestlé Research, EPFL Innovation Park, 1015, Switzerland.
  • Monteiro JP; Department of Pediatrics and Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo, Bandeirantes Avenue, 3900, Ribeirão Preto, 14049-900, Brazil.
  • Kaput J; Nestlé Research, EPFL Innovation Park, 1015, Lausanne, Switzerland.
  • Masoodi M; Lipid Metabolism, Nestlé Research, EPFL Innovation Park, 1015, Switzerland; Institute of Clinical Chemistry, Inselspital, Bern University Hospital, Bern, Switzerland. Electronic address: mojgan.masoodi@insel.ch.
Clin Nutr ; 39(7): 2211-2219, 2020 07.
Article em En | MEDLINE | ID: mdl-31677804
BACKGROUND: Micronutrient supplementation has been extensively explored as a strategy to improve health and reduce risk of chronic diseases. Fat-soluble vitamins like A and E with their antioxidant properties and mechanistic interactions with lipoproteins, have potentially a key impact on lipid metabolism and lipidemia. OBJECTIVE: The impact of micronutrients on lipid metabolism requires further investigation including characterization of plasma lipidome following supplementation and any cause-effect on circulating lipids. DESIGN: In this study, we elucidate the effect and associations of a multi-micronutrient intervention in Brazilian children and teens with lipoprotein alterations and lipid metabolism. RESULTS: Our analysis suggests a combination of short and long-term impact of supplementation on lipid metabolism, potentially mediated primarily by α-tocopherol (vitamin E) and retinol (vitamin A). Among the lipid classes, levels of phospholipids, lysophospholipids, and cholesterol esters were impacted the most along with differential incorporation of stearic, palmitic, oleic and arachidonic acids. Integrated analysis with proteomic data suggested potential links to supplementation-mediated alterations in protein levels of phospholipases and pyruvate dehydrogenase kinase 1 (PDK1). CONCLUSIONS: Associations between the observed differences in lipidemia, total triglyceride, and VLDL-cholesterol levels suggest that micronutrients may play a role in reducing these risk factors for cardiovascular disease in children. This would require further investigation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Micronutrientes / Suplementos Nutricionais / Hiperlipidemias / Lipídeos Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Clin Nutr Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suíça País de publicação: Reino Unido
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Micronutrientes / Suplementos Nutricionais / Hiperlipidemias / Lipídeos Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Clin Nutr Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suíça País de publicação: Reino Unido