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Prediabetes and Type 2 Diabetes are Independent Risk Factors for Computed Tomography-Estimated Nonalcoholic Fatty Pancreas Disease.
Ahbab, Süleyman; Ünsal, Ahmet; Ataoglu, Hayriye Esra; Can, Tuba Selçuk; Kayas, Derya; Savas, Yildiray.
Afiliação
  • Ahbab S; Internal Medicine Clinic, Haseki Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Ünsal A; Internal Medicine Clinic, Haseki Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Ataoglu HE; Internal Medicine Clinic, Haseki Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Can TS; Department of Radiology, Haseki Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Kayas D; Internal Medicine Clinic, Haseki Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Savas Y; Department of Radiology, Haseki Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Clinics (Sao Paulo) ; 74: e1337, 2019.
Article em En | MEDLINE | ID: mdl-31664423
OBJECTIVES: Nonalcoholic fatty pancreas disease (NAFPD) is characterized by excessive fat deposition in the pancreas in the absence of alcohol consumption. In this study, we aimed to detect a possible relationship between adipose tissue accumulation, prediabetes and diabetes. METHODS: This cross-sectional and retrospective study included 110 patients. Three groups were classified as controls, patients with prediabetes and patients with type 2 diabetes. The abdominal computed tomography (CT) attenuation measurement results of the pancreas were evaluated independently by two experienced radiologists. CT measurements and biochemical parameters were compared between study groups. The relationship between continuous variables was assessed by using one-way ANOVA. To determine the changes in the dependent variable for the effects on study groups, the independent variable was adjusted using ANCOVA. A p-value less than 0.05 was considered statistically significant. RESULTS: The presence of prediabetes and type 2 diabetes was correlated with a decrease in the mean Hounsfield Unit (HU) value of the pancreas (p=0.002). Age was determined to be an independent risk factor and was correlated with NAFPD (p=0.0001). When compared to the controls (p=0.041), 71% of patients with prediabetes and 67% of patients with type 2 diabetes were observed to have an increased incidence of NAFPD. Decreased serum amylase was found to be correlated with the mean HU value of the pancreas (p=0.043). CONCLUSION: NAFPD was independently correlated with both prediabetes and type 2 diabetes adjusted for age (p=0.0001) in this study. Additionally, age was determined to be an independent risk factor and was correlated with NAFPD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pancreatopatias / Diabetes Mellitus Tipo 2 Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Aspecto: Patient_preference Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Turquia País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pancreatopatias / Diabetes Mellitus Tipo 2 Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Aspecto: Patient_preference Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Turquia País de publicação: Estados Unidos