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Biomonitoring of pharmacists and nurses at occupational risk from handling antineoplastic agents.
Santos, Andreza Negreli; Oliveira, Rodrigo Juliano; Pessatto, Lucas Roberto; Gomes, Roberto da Silva; Freitas, Carlos Alberto Ferreira de.
Afiliação
  • Santos AN; Center for Stem Cell Research, Cell Therapy and Toxicological Genetics, Maria Aparecida Pedrossian University Hospital, Brazilian Company of Hospital Services, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
  • Oliveira RJ; Master's Program in Pharmaceutics, School of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
  • Pessatto LR; Center for Stem Cell Research, Cell Therapy and Toxicological Genetics, Maria Aparecida Pedrossian University Hospital, Brazilian Company of Hospital Services, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
  • Gomes RDS; Master's Program in Pharmaceutics, School of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
  • Freitas CAF; Dr. Hélio Mandetta School of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Int J Pharm Pract ; 28(5): 506-511, 2020 Oct.
Article em En | MEDLINE | ID: mdl-31663186
OBJECTIVE: The objective of this study was to evaluate the frequency of genetic lesions in pharmacists and nurses who prepare and/or handle antineoplastic agents and to evaluate whether there are traces of contaminants in the urine of these professionals. METHODS: A total of 59 professionals participated in the study, of which 10 were non-exposed professionals (controls), 25 were pharmacists, and 24 were nurses. KEY FINDINGS: There was a significant increase in genetic damage in lymphocytes and cells of the oral mucosa in both pharmacists and nurses. The levels of cyclophosphamide and ifosfamide were also increased in the urine samples from those individuals. CONCLUSIONS: These results demonstrate the growing need for genetic biomonitoring and biomonitoring of trace antineoplastic agents in the urine of health professionals who prepare and/or handle antineoplastic agents.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Farmacêuticos / Exposição Ocupacional / Monitoramento Biológico / Antineoplásicos / Enfermeiras e Enfermeiros Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Pharm Pract Assunto da revista: FARMACIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Farmacêuticos / Exposição Ocupacional / Monitoramento Biológico / Antineoplásicos / Enfermeiras e Enfermeiros Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Pharm Pract Assunto da revista: FARMACIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido